Evidence map›Paper›PMID 40693197›Full record

ReviewACS photonics2025

Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.

Cécile Telliez, Ruth Sims, Giulia Faini, Pascal Berto, Eirini Papagiakoumou, Dimitrii Tanese, Nicolò Accanto

Abstract readReview
In one paragraph

Review in ACS photonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cécile TelliezSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.
Ruth SimsSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.
Giulia FainiSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.
Pascal BertoSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.ORCID https://orcid.org/0000-0003-1664-257X
Eirini PapagiakoumouSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.
Dimitrii TaneseSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.
Nicolò AccantoSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris F-75012, France.ORCID https://orcid.org/0000-0003-2491-7190

Funding

Mesoscale bidirectional two-photon holographic optogeneticsRF1NS128772 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADESNIK, HILLEL · 2022 to 2022
$3.2M
Red-shifted voltage indicators for two-photon all-optical physiology and multi-spectral imagingR01NS136027 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Jacob Reimer, Francois St-Pierre · 2024 to 2026
$1.7M
NINDS NIH HHS R01 NS136027NINDS NIH HHS RF1 NS128772
6 · The paper itself

Abstract

The possibility of using light to image and manipulate neuronal activity, at the heart of Neurophotonics, has provided new irreplaceable tools to study brain function. In particular, the combination of multiphoton microscopy and optogenetics allows researchers to interact with neuronal circuits with single-cell resolution in living brain tissues. However, significant optical challenges remain to empower new discoveries in Neuroscience. This Review focuses on three critical areas for future development: (1) expanding imaging and optogenetic stimulation to larger fields of view and faster acquisition speeds, while maintaining single-cell resolution and minimizing photodamage; (2) enabling access to deeper brain regions to study currently inaccessible neuronal circuits; and (3) developing optical techniques for studying natural behaviors in freely moving animals. For each of these challenges, we review the current state-of-the-art and suggest future directions with the potential to transform the field.

Indexed as

All-optical brain studiesCalcium and voltage imagingMultiphoton microscopyNeurophotonicsOptogenetic photostimulationWavefront shaping

Identifiers

PMID40693197
PMCPMC12279007

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.