Evidence map›Paper›PMID 40693194›Full record

ArticleInfection and drug resistance2025

Clinical Characteristics and Mortality Risk Factors in Patients with Tuberculosis and Coincident

Xiaohong Pan, Jun Zheng, Jiekun Xu, Lei Pan, Caihong Wang, Xiaoqing Huang, Junke Qiu, Chenxi Yan, Minjie Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohong PanDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Jun ZhengDepartment of Rehabilitation, Health Service Center of Nanxing Subdistrict, Hangzhou, Zhejiang, 310000, People's Republic of China.
Jiekun XuDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Lei PanDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Caihong WangDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Xiaoqing HuangDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.ORCID 0009-0006-9727-6047
Junke QiuDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Chenxi YanDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.
Minjie MaoDepartment of Intensive Care Unit for Tuberculosis, Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310013, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: HIV infection and immunosuppressive therapy are major risk factors for tuberculosis (TB) or Methods: Patients diagnosed with TB and PJP at our center between January 2018 and December 2023 were retrospectively investigated. Data on demographics, diagnostic methods, clinical symptoms, imaging findings, laboratory examinations, treatment regimens, and clinical outcomes were collected from electronic medical records and summarized. The risk factors for mortality were then explored by logistic regression analysis, and the corresponding odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: In total, 26 patients were included (mean age, 61.6 ± 16.6 years; illness duration, 39.8 ± 53.1 days). All cases of PJP were diagnosed by next-generation sequencing. The most common symptoms were cough (88.5%), fever (84.6%), and shortness of breath (69.2%). Chest imaging predominantly revealed ground-glass opacities (57.7%). Six patients (23.1%) died during hospitalization. Multivariate analysis identified the oxygenation index (OR = 0.979, 95% CI = 0.976-0.982) and lymphocyte count (OR = 0.006, 95% CI = 0.002-0.017) as independent risk factors for mortality. Conclusion: Favorable clinical outcomes can be expected in most cases of coincident TB and PJP. However, decreases in the oxygenation index and lymphocyte count increase the risk of mortality.

Indexed as

Pneumocystis jirovecii pneumoniaprognosisrisk factorstuberculosis

Identifiers

PMID40693194
PMCPMC12278959

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