ArticleCureus2025
Cerebellopontine Angle Epidermoid Cyst With Malignant Transformation Into Squamous Cell Carcinoma: An Unusual Complication of a Benign Intracranial Tumor.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Epidermoid cysts of the cerebellopontine angle in pediatric population-an institutional surgical case series and review of literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermoid cysts (ECs) are typically located in the posterior cranial fossa, most commonly at the cerebellopontine angle (CPA). Although generally benign, the cyst's epithelial lining can undergo malignant transformation into squamous cell carcinoma (SCC), a rare occurrence associated with poor prognosis. We present the case of a 55-year-old woman with a history of migraines who was incidentally diagnosed with a right CPA lesion consistent with an EC at the age of 30. Twenty-five years later, she developed progressive right-sided hearing loss, tinnitus, vertigo, headache, dysgeusia, and gait disturbances. Histopathological examination confirmed malignant transformation of the EC into SCC, supported by immunohistochemical markers including p63, p40, CK5/6, and D2-40. She was treated with fractionated stereotactic radiotherapy, carboplatin-paclitaxel chemotherapy, and the immune checkpoint inhibitor pembrolizumab, demonstrating good treatment tolerance and clinical stability.
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