ArticleTobacco induced diseases2025
Regional and gender disparities in tobacco-related esophageal cancer: Insights from the Global Burden of Disease study 1990-2021.
Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tobacco-driven digestive disease burden: A China-US comparative analysis, 1990-2035.Tobacco induced diseases · 2026Article
- Tobacco-associated carcinogenesis with nicotine-mediated tumor promotion across the gastrointestinal tract: A narrative review.Tobacco prevention & cessation · 2026Review
- Global, regional, and national burden of smoking-attributable digestive cancers in adults aged ≥60 years, 1990-2021, with projections to 2036: A secondary dataset analysis of Global Burden of Disease (GBD) 2021.Tobacco induced diseases · 2026Article
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11 authors.
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Abstract
introductionTobacco-related esophageal cancer (TREC) is a major public health concern, with incidence and mortality rates rising globally. This study aims to analyze worldwide epidemiological data on TREC, examining its disease burden and temporal trends across regions, sexes, and age groups, in order to provide a theoretical basis for the development of targeted prevention policies.
methodsThis secondary dataset analysis utilized data from the Global Burden of Disease (GBD) 2021 study to examine the epidemiological features of TREC, focusing on mortality rates, disability-adjusted life years (DALYs), and other key indicators across regions and genders.
resultsFrom 1990 to 2021, global deaths due to TREC increased from 143332.8 to 219185.3, while the age-standardized death rate (ASDR) decreased from 3.6 to 2.5 per 100000 persons. The rise in TREC burden was primarily attributed to relative contributions from population growth (154.62%) and aging (39.75%). DALYs associated with TREC rose from 3844095.6 to 5136277, with a notable decline in age-standardized DALYs rate (ASDR) from 93.3 to 58.5 per 100000 persons. Significant regional and gender disparities were observed, with males experiencing a higher burden. Notably, China and India exhibited the most concerning epidemiological trends.
conclusionsThe findings highlight the need for targeted public health interventions to address the rising burden of TREC, particularly in regions with high smoking rates. While population growth and aging are key contributors, improvements in public health policies have the potential to mitigate the TREC burden in certain areas. Further research is necessary to explore additional factors influencing TREC epidemiology and to quantify the observed regional and gender differences.
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