Evidence map›Paper›PMID 40692841›Full record

ArticleERJ open research2025

Validity of the Chronic Airways Assessment Test (CAAT) in asthma, asthma+COPD and COPD in NOVELTY.

Paul W Jones, Erin L Tomaszewski, Laura Belton, Pierre-Régis Burgel, Rod Hughes, Christina Keen, Barry J Make, Alberto Papi, Hana Müllerová, Helen K Reddel and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02760329 (A NOVEL Observational longiTudinal studY on Patients With Asthma and/or COPD to Describe Patient Characteristics, Treatment Patterns and the Burden of Illness Over Time and to Identify Phenotypes and Endotypes.), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02760329 completednot on this map

A NOVEL Observational longiTudinal studY on Patients With Asthma and/or COPD to Describe Patient Characteristics, Treatment Patterns and the Burden of Illness Over Time and to Identify Phenotypes and Endotypes.

TypeobservationalSponsorAstraZenecaRan2016 to 2023Enrolled12,255ConditionsAsthma, COPD, Chronic Obstructive Pulmonary DiseaseArmsBlood draw, Urine, Lung function measurements, Fractional Exhaled Nitric Oxide (FENO)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Chronic Airways Assessment Test: performance and health predictors in the AlphaNet population.American journal of respiratory and critical care medicine · 2026
    Article
  3. Environmental prescribing for asthma and chronic obstructive pulmonary disease.African journal of primary health care & family medicine · 2026
    Article
  4. Article
  5. The importance of symptoms in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul W JonesGlobal Respiratory Franchise, GSK, Brentford, UK.ORCID https://orcid.org/0000-0001-6087-9182
Erin L TomaszewskiPatient Centered Science BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.
Laura BeltonBiostatistics, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Pierre-Régis BurgelDepartment of Respiratory Medicine, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID https://orcid.org/0000-0003-0903-9828
Rod HughesResearch and Early Development, Respiratory and Immunology, Clinical, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Christina KeenResearch and Early Development, Respiratory and Immunology, Clinical, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Barry J MakeNational Jewish Health and University of Colorado Denver, Denver, CO, USA.ORCID https://orcid.org/0000-0003-4349-8745
Alberto PapiRespiratory Medicine Unit, Department of Translational Medicine, Università di Ferrara, Ferrara, Italy.ORCID https://orcid.org/0000-0002-6924-4500
Hana MüllerováRespiratory Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Helen K ReddelThe Woolcock Institute of Medical Research and Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University; The University of Sydney; and Sydney Local Health District, Sydney, Australia.ORCID https://orcid.org/0000-0002-6695-6350
NOVELTY Scientific Community and the NOVELTY study investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To assess health status in respiratory diseases, the Chronic Airways Assessment Test (CAAT) was adapted from the COPD Assessment Test (CAT) by replacing COPD-specific wording. It has demonstrated good psychometric properties in asthma and/or COPD. This cross-sectional analysis evaluated how CAAT scores are associated with clinical characteristics in patients with asthma and/or COPD. Methods: Using baseline NOVELTY data (NCT02760329) for patients with physician-assigned asthma and/or COPD, linear regression models were implemented to assess the association between CAAT score (range 0-40; higher scores indicating worse health status) and physician-assessed severity, lung function, modified Medical Research Council dyspnoea grade, Respiratory Symptoms Questionnaire score and, for asthma and asthma+COPD, symptom control assessed by Asthma Control Test score. Results: Among 7828 patients (asthma: 4138; asthma+COPD: 991; COPD: 2699), CAAT score was lower in patients with asthma (mean±sd 14.0±8.5) Conclusion: The CAAT demonstrated consistent cross-sectional validity across asthma and/or COPD, making it applicable for assessing health status in these conditions in clinical practice and research.

Identifiers

PMID40692841
PMCPMC12278303

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.