Evidence map›Paper›PMID 40692744›Full record

ArticleMolecular and clinical oncology2025

Association of the expression of 5-FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S-1 adjuvant chemotherapy: Follow-up results of the Setouchi Lung Cancer Group Study 1201.

Junichi Soh, Hiromasa Yamamoto, Norihito Okumura, Hiroyuki Suzuki, Masao Nakata, Toshiya Fujiwara, Kenicehi Gemba, Isao Sano, Takuji Fujinaga, Masafumi Kataoka and 20 more

Abstract read
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In one paragraph

Article in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

30 authors.

Junichi SohDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.
Hiromasa YamamotoDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.
Norihito OkumuraDepartment of Thoracic Surgery, Kurashiki Central Hospital, Kurashiki, Okayama 710-8602, Japan.
Hiroyuki SuzukiDepartment of Chest Surgery, Fukushima Medical University Hospital, Fukushima 960-1295, Japan.
Masao NakataDepartment of General Thoracic Surgery, Kawasaki Medical School Hospital, Kurashiki, Okayama 701-0192, Japan.
Toshiya FujiwaraDepartment of Thoracic Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan.
Kenicehi GembaDepartment of Respiratory Medicine, Chugoku Central Hospital, Fukuyama, Hiroshima 720-0001, Japan.
Isao SanoDepartment of Respiratory Surgery, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki 852-8511, Japan.
Takuji FujinagaDepartment of General Thoracic Surgery, National Hospital Organization Nagara Medical Center, Gifu 502-8558, Japan.
Masafumi KataokaDepartment of Surgery and Respiratory Center, Okayama Saiseikai General Hospital, Okayama 700-8511, Japan.
Yasuhiro TerasakiDepartment of Respiratory Surgery, Saga Medical Center Koseikan, Saga 840-8571, Japan.
Nobukazu FujimotoDepartment of Medical Oncology and Respiratory Medicine, Okayama Rosai Hospital, Okayama 702-8055, Japan.
Kazuhiko KataokaDepartment of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Yamaguchi 740-8510, Japan.
Shinji KosakaDepartment of Thoracic Surgery, Shimane Prefectural Central Hospital, Izumo, Shimane 693-8555, Japan.
Motohiro YamashitaDepartment of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
Hidetoshi InokawaDepartment of Thoracic Surgery, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Yamaguchi 755-0241, Japan.
Masaaki InoueDepartment of Thoracic Surgery, Shimonoseki City Hospital, Shimonoseki, Yamaguchi 750-8520, Japan.
Hiroshige NakamuraDivision of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori 683-8504, Japan.
Yoshinori YamashitaDepartment of Thoracic Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima 737-0023, Japan.
Yuta TakahashiDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.
Hidejiro TorigoeDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.
Hiroki SatoDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.
Shuta TomidaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Katsuyuki HottaCenter for Innovative Clinical Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Hiroshige YoshiokaDepartment of Thoracic Oncology, Kansai Medical University Hospital, Hirakata, Osaka 573-1191, Japan.
Satoshi MoritaDepartment of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan.
Junichi SakamotoTokai Central Hospital, Kakamigahara, Gifu 504-8601, Japan.
Hiroshi DateDepartment of Thoracic Surgery, Kyoto University Hospital, Kyoto 606-8507, Japan.
Shinichi ToyookaDepartment of Thoracic Surgery, Okayama University Hospital, Okayama 700-8558, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Managing elderly patients presents several challenges because of age-related declines; however, age should not be the sole determinant for adjuvant treatment decisions in patients with non-small cell lung cancer (NSCLC). Moreover, age may affect the expression of 5-fluorouracil (5-FU) biomarkers. The present study assessed: i) The effect of age on the expression levels of 5-FU biomarkers by analyzing a public database; and ii) the ability of these biomarkers to predict clinical outcomes in elderly patients with NSCLC who underwent complete resection in the Setouchi Lung Cancer Group Study 1201 (SCLG1201) followed by S-1 adjuvant chemotherapy. Changes in gene expression levels across age groups were assessed by analyzing The Cancer Genome Atlas (TCGA) database. The expression of 5-FU biomarkers, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase, epidermal growth factor receptor (EGFR) and excision repair cross-complementation group 1 (ERCC1), were assessed via quantitative reverse-transcription PCR assays in 89 elderly patients (≥75 years) with NSCLC who received adjuvant chemotherapy with oral fluoropyrimidine prodrug S-1 in the SLCG1201 trial. TCGA database analysis (n=955) showed that

Indexed as

adjuvant chemotherapyDPDEGFRelderly patientsERCC1non-small cell lung cancerOPRTS-1TPTS

Identifiers

PMID40692744
PMCPMC12278714

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