Evidence map›Paper›PMID 40692737›Full record

ArticleClinical and translational discovery2025

A Snapshot of the Role of Estrogen-Regulated Divergent Non-Coding Transcripts.

Barbara Yang, Melina J Sedano, Kimberly Diwa, Johnathan Dominguez, Gabriela Boisselier, Alana L Harrison, Victoria A Reid, Enrique I Ramos, Maria V Jimenez, Laura A Sanchez-Michael and 7 more

Abstract read
In one paragraph

Article in Clinical and translational discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Barbara YangCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Melina J SedanoCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Kimberly DiwaL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Johnathan DominguezL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Gabriela BoisselierL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Alana L HarrisonCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Victoria A ReidCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Enrique I RamosThe University of Texas at El Paso, Texas-79968, United States.
Maria V JimenezPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Laura A Sanchez-MichaelL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Shreya KolliPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Jai PatelCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Debra LeePaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Mahalakshmi VijayaraghavanCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Jessica ChaconPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
Subramanian DhandayuthapaniSouth Texas Center of Excellence in Cancer Research, Department of Medicine and Oncology, The University of Texas Rio Grande Valley School of Medicine, McAllen, Texas-78504, United States.
Shrikanth S GadadCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.

Funding

A Novel Hyper-Immunogenic Low Virulent BCG vaccine against TuberculosisR01AI175837 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SUBRAMANIAN DHANDAYUTHAPANI · 2023 to 2026
$2.0M
A novel quadruple knockout MTb vaccine against tuberculosis (Supplement Resubmission)R15AI156647 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO · PI DHANDAYUTHAPANI, SUBRAMANIAN · 2021 to 2023
$626k
Analysis of Divergent Transcripts in Estrogen-Dependent SignalingR16GM149497 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Shrikanth Gadad · 2023 to 2026
$620k
NIAID NIH HHS R01 AI175837NIAID NIH HHS R15 AI156647NIGMS NIH HHS R16 GM149497
6 · The paper itself

Abstract

Recent high-throughput sequencing technologies have discovered various polymerase II transcribed transcripts. The majority of them are non-protein-coding, understudied, and poorly conserved. Noncoding transcripts are categorized based on their location in the genome and the direction in which they are transcribed; these categories classify a noncoding transcript as either antisense, intergenic, or divergent. The RNAs belonging to divergent classes consist of two transcripts, transcribed in sense and antisense direction, generated from the same promoter or locus. Multiple environmental and genetic cues can determine the regulation of these transcripts. One of the well-known signaling molecules, estrogen, has been shown to play a vital role in the activation and regulation of divergent transcripts by mediating effects through the estrogen receptors. Emerging studies have shown a strong causative effect between estrogen-regulated divergent transcripts and diseases such as cancer. However, few, viz.,

Indexed as

breast cancercancerestrogenLong noncoding RNAssignaling

Identifiers

PMID40692737
PMCPMC12276875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.