ArticleFrontiers in cellular and infection microbiology2025
Exploring the bioactive compounds of
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Antigonococcal Activity and Cytotoxicity Screening of Three Ziziphus Species Indigenous to South Africa.Chemistry & biodiversity · 2026Article
- Ethnobotanical Survey of Medicinal Plants Utilized by Traditional Healers in Managing Respiratory Tract Infections in the Kagera Region, Tanzania.TheScientificWorldJournal · 2026Article
- In Vitro Insights into the Antifungal, Prebiotic, and Cytotoxic Potential of Tomato Plant Waste.Nutrients · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Antibiotic resistance is a pressing global challenge, complicating the treatment of infectious diseases caused by multidrug-resistant microorganism. For centuries, medicinal plants have been a cornerstone of natural remedies, offering bioactive compounds with therapeutic potential. Methods: The study investigate the phytochemical screening and antibacterial efficay of Results: The phytochemical screening revealed the presence of phenols and flavonoids, which are key contributors to the extract's biological activity. GC-MC analysis identified 27 bioactive compounds, with phytol emerging as a prominent constituent, detected at a peak retention time of 18.712 minutes. Antibacterial assays demonstrated significant efficacy, with inhibitory zones ranging from 10 to 20 mm against the tested pathogens. Molecular docking further highlighted phytol's strong binding affinities to crucial bacterial proteins, including DNA gyrase ( Discussion: These findings position phytol as a promising lead compound for developing novel antibacterial therapies. Its strong activity against multidrug-resistant pathogens suggests potential for further exploration, though additional research is needed to assess its role in resistance modulation or prevention.
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Registered trials
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