Evidence map›Paper›PMID 40692677›Full record

ArticleGut microbiome (Cambridge, England)2025

Dietary iron interacts with diet composition to modulate the endocannabinoidome and the gut microbiome in mice.

Fredy Alexander Guevara Agudelo, Nadine Leblanc, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Fadil Dahhani, Nicolas Flamand, Alain Veilleux, Vincenzo Di Marzo, Frédéric Raymond

Abstract read
In one paragraph

Article in Gut microbiome (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Dietary Manganese Modulates Microbiota and Intestinal N-Acylethanolamines in a Sex-Specific Manner in Mice With Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fredy Alexander Guevara AgudeloCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.ORCID https://orcid.org/0000-0003-2758-6964
Nadine LeblancCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.
Isabelle Bourdeau-JulienCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.
Gabrielle St-ArnaudCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.
Fadil DahhaniChaire d'excellence en recherche du Canada sur l'axe microbiome - endocannabinoidome dans la santé métabolique (CERC-MEND), Québec, Canada.
Nicolas FlamandChaire d'excellence en recherche du Canada sur l'axe microbiome - endocannabinoidome dans la santé métabolique (CERC-MEND), Québec, Canada.
Alain VeilleuxCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.
Vincenzo Di MarzoCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.
Frédéric RaymondCentre Nutrition, santé et société (NUTRISS), et Institut sur la Nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, Canada.ORCID https://orcid.org/0000-0002-3606-4060

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endocannabinoidome (eCBome) and the gut microbiota have been implicated in diet-induced obesity and impaired metabolism. While the eCBome and the gut microbiome are known to respond to diet macronutrient composition, interaction with micronutrient intake has been relatively unexplored. Iron (Fe) is an essential micronutrient for the function of enzymes involved in energy and lipid metabolism. Here, we evaluated how 28 days of Fe depletion and enrichment, in interaction with Low Fat-Low Sucrose (LFLS) or High Fat-High Sucrose (HFHS) diets, affect the host via the eCBome, and modulate intestinal gut microbial communities. Circulating levels of

Indexed as

endocannabinoid (eCB) systeminflammationintestineironmetabolic healthmicrobiomenutrition

Identifiers

PMID40692677
PMCPMC12277099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.