ArticleFrontiers in bioengineering and biotechnology2025
Design, synthesis, and anti-inflammatory potential of PROTAC drug molecules based on fondaparinux sodium.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- AI-assisted design and virtual profiling of targeted degraders for pancreatic cancer therapy via PROTAC technology.American journal of cancer research · 2026Article
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7 authors.
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Abstract
Introduction: In this study, we used an approach by conjugating Fondaparinux Sodium (FS) with selected drugs to generate proteolysis-targeting chimeras (PROTACs). Methods: By applying bioprocess engineering principles, the direct amidation reaction was optimized -through precise control of pH, substrate ratios, and solvent selection -to reliably produce high-purity (>99%) PROTAC molecules on a scalable platform. Surface plasmon resonance (SPR) analysis demonstrated that the synthesized PROTACs exhibit micromolar binding affinities (KD ≈ 10 Results: High-purity (>99%) PROTAC molecules were produced on a scalable platform. The synthesized PROTACs demonstrated micromolar binding affinities (KD ≈ 10 Discussion: These findings not only provide an innovative strategy for targeting "undruggable" proteins but also establish a robust, scalable process for the production of PROTAC-based anti-inflammatory agents.
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