ArticleFrontiers in neurology2025
Fatigue and its correlation with anxiety and depression in patients with multiple sclerosis in China.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Relationship status and the neurobehavioral symptoms of multiple sclerosis: a cross-sectional analysis.Journal of neurology · 2026Article
- Assessing the relation between fatigue and depression in multiples sclerosis: the impact of measurement choice.Frontiers in immunology · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Multiple Sclerosis (MS) is a chronic, progressive, immune-mediated disease of the central nervous system. Fatigue is a common and disabling symptom in patients with MS (PwMS). Some psychological factors, such as depression, stress, and anxiety, also appear to be related to these issues. Objectives: The study aimed to investigate the fatigue conditions of PwMS in China and its influencing factors, as well as to explore the correlation between fatigue with anxiety and depression. Methods: This study was a cross-sectional study conducted through the Internet, which collected demographic characteristics, clinical data, Modified Fatigue Impact Scale (MFIS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II). Results: A total of 366 PwMS were included in this study. MFIS showed a median fatigue total score of 40.0 (interquartile range [IQR] 26.0-52.0), with 55.7% ( Conclusion: The prevalence of fatigue among Chinese PwMS is 55.7%. Age, education, employment, marital status, type of disease, and disease duration are all factors influencing the fatigue rate in PwMS. Fatigue in PwMS exhibit strong positive correlations with depression and anxiety.
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