ArticleJournal of inflammation research2025
Susceptibility Factor TNF-α Synergizes with
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adipose-derived stem cell extracellular vesicles attenuate liver fibrosis via restoration of gut barrier function and modulation of gut microbiota.Extracellular vesicles and circulating nucleic acids · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: This study sought to elucidate the role of TNF-α in PM-IDILI using a TNF-α-sensitized C57BL/6J mouse model, integrating analyses of the gut microbiota and metabolomics We employed biochemical analysis, inflammatory markers, inflammatory liver histopathological, sequencing of 16S rRNA gene, as well as untargeted metabolomics based on LC-MS to systematically evaluate the extent of liver injury and characterize alterations in gut microbiota and liver metabolites following PM administration in TNF-α pre-treated mice. Results: The results demonstrated that PM treatment in TNF-α-sensitized mice significantly elevated levels of indicators as AST (3.6-fold compared to the control group, Conclusion: These findings suggest that TNF-α sensitization predisposes mice to PM-IDILI, potentially by disrupting gut microbial homeostasis and altering host hepatic metabolism. This research provides critical theoretical and experimental evidence relevant to the safe and effective clinical application of PM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.