Evidence map›Paper›PMID 40692495›Full record

Trial reportPsychological medicine2025

A dismantling study of comprehensive cognitive remediation for improving employment outcomes: what is the role of computer cognitive training?

Susan R McGurk, Kim T Mueser, Haiyi Xie, Philippe Bloch, Nicole R DeTore, Nicole Pashka, Susan Guarino, Anabelle Ruiz, Clara Elliot, Heather Gagnon and 7 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07749105 (Enhancing Cognitive and Work/School Outcomes in People With First Episode Psychosis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07749105 narecruitingnot on this map

Enhancing Cognitive and Work/School Outcomes in People With First Episode Psychosis: Testing the Effectiveness of Cognitive Self-Management Strategies

TypeinterventionalSponsorBoston University Charles River CampusRan2025 to 2029Enrolled60ConditionsFirst Episode Psychosis (FEP)ArmsThinking Skills for Work-Cognitive Self-Management Program (CSM), Treatment as Usual (TAU)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Susan R McGurkCenter for Psychiatric Rehabilitation, https://ror.org/05qwgg493Boston University, Boston, MA, USA.ORCID 0000-0001-5091-3033
Kim T MueserCenter for Psychiatric Rehabilitation, https://ror.org/05qwgg493Boston University, Boston, MA, USA.ORCID 0000-0002-1482-8314
Haiyi XieDepartment of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Philippe BlochCenter for Psychiatric Rehabilitation, https://ror.org/05qwgg493Boston University, Boston, MA, USA.
Nicole R DeToreDepartment of Psychiatry, https://ror.org/002pd6e78Massachusetts General Hospital, Boston, MA and Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA.ORCID 0000-0002-4714-1973
Nicole Pashkahttps://ror.org/01dp3s597Thresholds, Inc., Chicago, IL, USA.
Susan GuarinoThe Mental Health Center of Greater Manchester, Manchester, NH, USA.
Anabelle Ruizhttps://ror.org/01dp3s597Thresholds, Inc., Chicago, IL, USA.
Clara Elliothttps://ror.org/01dp3s597Thresholds, Inc., Chicago, IL, USA.
Heather GagnonThe Mental Health Center of Greater Manchester, Manchester, NH, USA.
Edward BaileyThe Mental Health Center of Greater Manchester, Manchester, NH, USA.
Virginia Fraserhttps://ror.org/01dp3s597Thresholds, Inc., Chicago, IL, USA.
Jason WelshThe Mental Health Center of Greater Manchester, Manchester, NH, USA.
Harry CunninghamThe Mental Health Center of Greater Manchester, Manchester, NH, USA.
Lisa Rizzanohttps://ror.org/01dp3s597Thresholds, Inc., Chicago, IL, USA.
Rosemarie WolfeDepartment of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Robert E DrakeDepartment of Psychiatry, https://ror.org/00hj8s172Columbia University, New York, NY, USA.

Funding

Evaluation of BDNF as a Mediator of the Effects of Cognitive Remediation in persons with SMIR01MH077210 · NIMH · DARTMOUTH COLLEGE · PI MCGURK, SUSAN R. · 2006 to 2016
$4.1M
NIMH NIH HHS R01 MH077210
6 · The paper itself

Abstract

backgroundComprehensive cognitive remediation improves cognitive and functional outcomes in people with serious mental illness, but the specific components required for effective programs are uncertain. The most common methods to improve cognition are facilitated computerized cognitive training with coaching and teaching cognitive self-management strategies. We compared these methods by dismantling the Thinking Skills for Work program, a comprehensive, validated cognitive remediation program that incorporates both strategies.

methodsIn a randomized controlled trial we assigned 203 unemployed people with serious mental illness in supported employment programs at two mental health agencies to receive either the full Thinking Skills for Work (TSW) program, which included computerized cognitive training (based on Cogpack software), or the program with cognitive self-management (CSM) but no computer training. Outcomes included employment, cognition, and mental health over 2 years. To benchmark outcomes, we also examined competitive work outcomes in a similar prior trial comparing the TSW program with supported employment only.

resultsThe TSW and CSM groups improved significantly on all outcomes, but there were no differences between the groups. Competitive work outcomes for both groups resembled those of the TSW program in a prior trial and were better than the supported employment-only group in that study, suggesting that participants in both groups benefited from cognitive remediation.

conclusionsProviding facilitated computerized cognitive training improved neither employment nor cognitive outcomes beyond teaching cognitive self-management strategies in people receiving supported employment. Computerized cognitive training may not be necessary for cognitive remediation programs to improve cognitive and functional outcomes.

Indexed as

Cognitive RemediationEmploymentEmployment, SupportedMental DisordersTherapy, Computer-AssistedAdultCognitive TrainingFemaleHumansMaleMiddle AgedSelf-ManagementTreatment Outcomecognitive remediationcognitive trainingemploymentsevere mental illness

Identifiers

PMID40692495
PMCPMC12315654

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.