ArticleJournal of gastroenterology and hepatology2025
High Neutrophil-to-Lymphocyte Ratio Predicts a Suppressive Immune Microenvironment and Basal-Like Subtype in Pancreatic Cancer.
Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Intersecting Roles of Estrogens and Neutrophils in Modulating Innate Immunity in Cancer.Biomolecules · 2026Review
- Baseline inflammatory and metabolic indicators associated with early PD-1 inhibitor resistance in advanced cervical cancer: a retrospective cohort study.Frontiers in medicine · 2026Article
- High Neutrophil-to-Lymphocyte Ratio Predicts a Suppressive Immune Microenvironment and Basal-Like Subtype in Pancreatic Cancer.Journal of gastroenterology and hepatology · 2025Article
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10 authors.
Funding
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR) has been utilized as a biomarker predicting prognosis in various cancers. However, it is uncertain whether NLR reflects the immunologic portrait or the molecular subtype of pancreatic cancers.
methodsTotal 64 pancreatic cancer patients who underwent surgical resection were enrolled and their preoperative serum NLR was calculated. Immunohistochemistry for CD8, CD15, CK5, and GATA6 was performed on tumor tissues to investigate the immunologic microenvironment or molecular subtype of the tumor. ΔNp63 transfection in pancreatic cancer cell lines and subsequent cytokine array were done to investigate the mechanism.
resultsIn the clinicopathologic analyses, high-NLR (≥ 3.29) was associated with adenosquamous histology (p = 0.009) and the significantly worse overall (p = 0.003) or disease-free survivals (p = 0.044). In line with the value of serum NLR, tumors in the high-NLR group contained more neutrophils (p = 0.0198) but fewer T lymphocytes (p = 0.0463) than in the low-NLR group. Most of the tumors in the high-NLR group were determined to be the basal-like subtype (p = 0.002). Transfection of ΔNp63, a known key transcription factor driving the basal-like subtype, led to a substantial increase of CCL5, which is a potent chemokine to recruit neutrophils.
conclusionsHigh preoperative NLR is a simple but reliable biomarker predicting a worse prognosis in pancreatic cancer patients, mechanistically because this reflects a suppressive immune microenvironment and also is strongly linked to the aggressive basal-like subtype. Our study provides a rationale to use the NLR for tailored therapy as well as for predicting prognosis.
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