Evidence map›Paper›PMID 40692446›Full record

ArticleThe Journal of infectious diseases2025

Long-term Kinetics of Vibriocidal Antibody Responses After Vibrio cholerae Infection in the Democratic Republic of Congo.

Kilee L Davis, Carmen Nieznanski, Felicien M Maisha, Ben J Brintz, Christy H Clutter, Meer T Alam, Cyrus Saleem, Afsar Ali, J Glenn Morris, Daniel T Leung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kilee L DavisDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City.ORCID 0009-0000-5198-9099
Carmen NieznanskiDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City.ORCID 0009-0009-1127-7877
Felicien M MaishaDepartment of Sociology, College of Humanity and Social Sciences, University of Goma, Democratic Republic of Congo.
Ben J BrintzDivision of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.ORCID 0000-0003-4695-0290
Christy H ClutterDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City.ORCID 0000-0001-6236-5636
Meer T AlamEmerging Pathogens Institute, University of Florida, Gainesville.
Cyrus SaleemEmerging Pathogens Institute, University of Florida, Gainesville.ORCID 0000-0002-9112-4441
Afsar AliEmerging Pathogens Institute, University of Florida, Gainesville.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville.ORCID 0000-0001-9347-1984
Daniel T LeungDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City.ORCID 0000-0001-8401-0801

Funding

Cholera in Goma, DRCR01AI138554 · NIAID · UNIVERSITY OF FLORIDA · PI MORRIS, JOHN GLENN · 2019 to 2023
$3.8M
Estimating Cholera Burden with Cross-sectional Immunologic DataR01AI135115 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2018 to 2022
$3.4M
Global MedicineNIAID NIH HHS R01 AI135115NIAID NIH HHS R01 AI138554NIH HHS R01AI135115NIH HHS R01AI138554University of Utah Undergraduate Research Opportunities Program
6 · The paper itself

Abstract

Interpretation of seroepidemiology studies of cholera relies on knowledge of antibody kinetics, which are not well known in African populations. We performed vibriocidal antibody assays on 212 serum samples from 115 patients with culture-positive cholera (median age, 8 years) in Goma, Democratic Republic of Congo, which were collected at enrollment and 3 to 449 days after. Vibriocidal responses peaked at 7 to 40 days after symptom onset, with 89.5% waning to a titer ≤160 by 180 days. We used a bayesian exponential decay model to show an 88% probability of the posterior distribution supporting a faster decay in children ≤5 years of age.

Indexed as

Antibodies, BacterialCholeraVibrio choleraeAdolescentAdultBayes TheoremChildChild, PreschoolDemocratic Republic of the CongoFemaleHumansInfantMaleMiddle AgedSeroepidemiologic StudiesYoung AdultAntibodies, Bacterialantibody kineticscholeraseroepidemiologyvibriocidal

Identifiers

PMID40692446
PMCPMC12526859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.