Evidence map›Paper›PMID 40692442›Full record

ArticleActa biochimica et biophysica Sinica2025

LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.

Langlin Ou, Zitong Meng, Jian Mei, Hao Yuan, Xiangrui Zhu, Xiaoying Wang, Ao Shen, Zhaosi Wang, Lixin Zhang, Song Wang and 5 more

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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Langlin OuCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Zitong MengCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Jian MeiCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Hao YuanCollege of Pharmacy, Harbin Medical University, Harbin 150081, China.
Xiangrui ZhuCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Xiaoying WangCollege of Pharmacy, Harbin Medical University, Daqing 163319, China.
Ao ShenCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Zhaosi WangCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Lixin ZhangCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Song WangBasic Medical College, Harbin Medical University, Daqing 163319, China.
Yingli ChenCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Xiangming PangCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Yuxiang LiuCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.
Yadong XuDepartment of Pulmonary and Critical Care Medicine, Daqing People's Hospital, Daqing 163316, China.
Cui MaCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing 163319, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cuproptosis is a recently identified form of copper-driven cell death characterized by the aggregation of acylated proteins and proteotoxic stress in the mitochondrial tricarboxylic acid cycle, which plays a role in inflammation. Recent studies suggest that hexokinase structural domain protein 1 (HKDC1), a fifth hexokinase, is involved in regulating mitochondrial function. However, the role of HKDC1 in cuproptosis and LPS-induced macrophage inflammation remains unclear. Here, we assess macrophage plasticity using CCK8 viability assays and phagocytosis activity experiments in an

Indexed as

cuproptosisglycolysisHKDC1inflammationLPS

Identifiers

PMID40692442
PMCPMC12748187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.