Evidence map›Paper›PMID 40692441›Full record

ArticleActa biochimica et biophysica Sinica2025

Nobiletin suppresses nasopharyngeal carcinoma by regulating the KEAP1/NRF2/ARE pathway.

Yiyao Liang, Minyan Wei, Yunan Yao, Baizhong Chen, Jinji Deng, Shiqi Xu, Liming Li, Wen Liu, Yi Cai, Guodong Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiyao LiangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Minyan WeiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Yunan YaoGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Baizhong ChenGuangdong Xinbaotang Biological Technology Co., Ltd., Jiangmen 529100, China.
Jinji DengGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Shiqi XuSchool of Public Health, Guangzhou Medical University, Guangzhou 511436, China.
Liming LiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Wen LiuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Yi CaiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Guodong ZhengGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) ranks among the most prevalent malignancies, particularly in East Asia and Southeast Asia. Nobiletin (NOB), an exclusive polymethoxyflavonoid derived from citrus peel, exhibits diverse physiological properties, notably its potent anticancer activity. Kelch-like ECH-associated protein 1 (KEAP1), the repressor protein regulating the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor, has emerged as a promising strategy for addressing oxidative stress in various diseases. The KEAP1/NRF2/ARE signal is a fundamental pathway within the cellular homeostatic defense system. This study robustly demonstrates the chemopreventive potential of NOB through comprehensive

Indexed as

Antioxidant Response ElementsFlavonesFlavonolsKelch-Like ECH-Associated Protein 1Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsNF-E2-Related Factor 2Signal TransductionAnimalsCell Line, TumorCell MovementHumansMiceMice, Inbred BALB CMice, NudeXenograft Model Antitumor AssaysFlavonesFlavonolsKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2nobiletinactivatorKEAP1nasopharyngeal cancerNobiletinNRF2oxidative stress

Identifiers

PMID40692441
PMCPMC12666671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.