Evidence map›Paper›PMID 40692400›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Minimally Invasive Chemical Biopsy Needle with Self-Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures.

Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Runshan Will JiangDepartment of Chemistry, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.ORCID https://orcid.org/0000-0001-9111-8001
Wei ZhouDepartment of Chemistry, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.ORCID https://orcid.org/0000-0001-9817-0646
Marcelo CypelLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, M5G 0A3, Canada.ORCID https://orcid.org/0000-0001-5652-1938
Todd L DemmyDepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.ORCID https://orcid.org/0000-0002-4800-2297
Gal ShafirsteinDepartment of Cell Stress Biology, Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.ORCID https://orcid.org/0000-0003-4413-9330
Guillermo GarzaLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, M5G 0A3, Canada.
Emily GawrysDepartment of Cell Stress Biology, Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.
Joanna BogusiewiczDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, 85-067, Poland.ORCID https://orcid.org/0000-0003-4429-6854
Barbara BojkoDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, 85-067, Poland.ORCID https://orcid.org/0000-0003-3971-9816
Janusz PawliszynDepartment of Chemistry, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.ORCID https://orcid.org/0000-0002-9975-5811

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Interstitial Chemophototherapy with Light-Activated Nanoparticulate DoxorubicinR42CA243954 · NCI · POP BIOTECHNOLOGIES, INC · PI SHAFIRSTEIN, GAL · 2022 to 2023
$2.0M
NCI NIH HHS P30 CA016056NCI NIH HHS R42 CA243954
6 · The paper itself

Abstract

Chemical biopsy by solid-phase microextraction (SPME) with sorbent-coated fibers offers monitoring of biological processes in a significantly less invasive manner compared to conventional tissue biopsy. The developed device features a self-protective design by using an acupuncture needle coated with biocompatible material only in a recessed section. The coating comprises micron-sized naturally wettable sorbent particles embedded in a durable, biocompatible binder, ensuring broad analyte extraction coverage without the need for solvent activation. This design allows professionals in biochemical research and medical staff to use the device for in vivo monitoring of tissue concentrations of endogenous and/or exogenous substances without introducing activation solvent to the investigated system. The device is successfully used to sample anti-cancer drugs in both animal models and human patients undergoing in vivo lung perfusion (IVLP) surgery, and then determine the drug concentration level by LC/MS. Finally, a proof-of-concept experiment using a microfluidic open interface (MOI) to directly desorb and introduce the extract analytes from the coating to MS detection is proposed for potential on-site real-time drug monitoring during the surgery.

Indexed as

Solid Phase MicroextractionAnimalsEquipment DesignHumansNeedlesdrug monitoringin vivo lung perfusionin vivo samplingsolid‐phase microextractiontissue sampling

Identifiers

PMID40692400
PMCPMC12767110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.