Evidence map›Paper›PMID 40692397›Full record

ArticleAnimal science journal = Nihon chikusan Gakkaiho

Changes in Antimicrobial Component Concentrations at the Onset of the Dry Period and Peripartum in Dairy Cows.

Jirapat Jaisue, Jinkun Sun, Nur Laili Marufah, Masashi Itagaki, Naoki Isobe

Abstract read
In one paragraph

Article in Animal science journal = Nihon chikusan Gakkaiho. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jirapat JaisueGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.ORCID https://orcid.org/0009-0000-4437-9399
Jinkun SunGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
Nur Laili MarufahGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.ORCID https://orcid.org/0000-0003-3598-2107
Masashi ItagakiJapan IMI, LLC, Yamagata, Japan.
Naoki IsobeGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.ORCID https://orcid.org/0000-0001-9230-6346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to clarify antimicrobial component (AMC) dynamics during the dry period in dairy cows and determine the impacts of varying somatic cell count (SCC) at the onset of the dry period on the subsequent changes in AMC concentrations in milk. Milk samples obtained from Holstein dairy cows were categorized into low-SCC and high-SCC groups. AMC concentrations in milk were measured at four time points: (1) Onset of the dry period, (2) before calving, (3) immediately after calving, and (4) 1 week postpartum. In the low-SCC group, SCC and lingual antimicrobial peptide increased prepartum but decreased 1 week postpartum. Milk lactoperoxidase and lactoferrin concentrations increased prepartum but declined after calving, while cathelicidin-7, S100A7, and S100A8 concentrations increased after calving compared to those prepartum in both groups. S100A7 concentrations in the low-SCC group were significantly higher than those in the high-SCC group prepartum and immediately after calving. However, S100A8 concentrations in the low-SCC group were significantly lower than those in the high-SCC group prepartum and 1 week postpartum. These results suggest that some AMCs were elevated after the onset of the dry period and immediately after calving and highlight the importance of mitigating inflammation in the mammary glands before the onset of the dry period.

Indexed as

Antimicrobial PeptidesMilkPeripartum PeriodAnimalsbeta-DefensinsCalgranulin ACathelicidinsCattleCell CountFemaleLactationLactoferrinLactoperoxidasePostpartum PeriodPregnancyS100 Calcium Binding Protein A7Antimicrobial Peptidesbeta-DefensinsCalgranulin ACathelicidinsLactoferrinLactoperoxidaselingual antimicrobial peptideS100 Calcium Binding Protein A7antimicrobial substancedrying‐offinflammationmastitis

Identifiers

PMID40692397
PMCPMC12281073

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.