Evidence map›Paper›PMID 40692330›Full record

ArticleHistology and histopathology2026

Xintian Zheng, Shengni Lv, Wangen Wang, Liangrong Zhu, Luning Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xintian ZhengTraditional Chinese Medicine Pharmacy, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Taizhou, Zhejiang, China.
Shengni LvTraditional Chinese Medicine Pharmacy, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Taizhou, Zhejiang, China.
Wangen WangTraditional Chinese Medicine Pharmacy, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Taizhou, Zhejiang, China.
Liangrong ZhuDispensary for Western Medicine, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Taizhou, Zhejiang, China.
Luning LinTraditional Chinese Medicine Pharmacy, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Taizhou, Zhejiang, China. linluning123@163.com.

Funding

Wenling Social Development Science and Technology Project 2022S00084Zhejiang Chinese Medical University Research Foundation 2022FSYYZQ34
6 · The paper itself

Abstract

objectivesKidney stones are a frequent urinary system disorder.

methodsThe function of the aqueous extract of LCH was assessed using kidney stone rat models induced by 1% ethylene glycol+2% NH4Cl. Additionally, an

resultsResultantly, the treatment of aqueous extract of LCH at different concentrations or LCH+LY294002 (PI3K-specific inhibitor) showed significant improvement in inorganic ions and renal pathological injury in nephrolithiasis rats. Besides, consistent with the

conclusionThis study shows that LCH ameliorates the kidney damage in kidney stone rats and HK-2 cells. The mechanism of LCH in treating kidney stones is related to the activation of the Nrf2/HO-1 axis and the inhibition of the PI3K/Akt/mTOR pathway.

Indexed as

Kidney CalculiOxidative StressPlant ExtractsAnimalsCalcium OxalateCell LineDisease Models, AnimalHumansKidneyLysimachiaMalePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionCalcium OxalatemTOR protein, ratPhosphatidylinositol 3-KinasesPlant ExtractsProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Identifiers

PMID40692330

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.