Evidence map›Paper›PMID 40692216›Full record

Observational studyPediatric blood & cancer2025

High Prevalence of Abnormal Baseline Lung Function in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Report from the TRANSPIRE Study.

Jane Koo, Richard Cooper, Stephanie L Edwards, Adam Lane, Sara Katherine Loveless, Lauren Strecker, Kelly E Lake, Kasiani C Myers, Christopher Towe, Jessica Patti and 31 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04098445 (TRANSPIRE), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04098445 recruitingnot on this map

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2021 to 2033Enrolled2,000ConditionsHematopoietic Stem Cell Transplant (HSCT), Diffuse Alveolar Hemorrhage, Thrombotic Microangiopathies, Interstitial Pneumonitis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Jane KooDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0003-1858-2881
Richard CooperDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Stephanie L EdwardsDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Adam LaneDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Sara Katherine LovelessDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lauren StreckerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Kelly E LakeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Kasiani C MyersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-5528-4405
Christopher ToweDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jessica PattiPulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Laura L WalkupDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Kathryn A Wikenheiser-BrokampDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Margaret L MacMillanPediatrics, Blood and Marrow Transplantation & Cellular Therapy Program, University of Minnesota, Minneapolis, Minnesota, USA.
Philip LacherBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA.
Tamara GriffinBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA.
Merve TekmanBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA.
Gabriel Salinas CisnerosDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, UCSF Benioff Children's Hospital, San Francisco, California, USA.
Kevin WuDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, UCSF Benioff Children's Hospital, San Francisco, California, USA.ORCID https://orcid.org/0009-0000-8909-6536
Matthew S ZinterPediatric Critical Care Medicine, UCSF Benioff Children's Hospitals, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-3351-3278
Fernando A UrregoDivision of Pulmonary Medicine, University of California San Francisco, San Francisco, California, USA.
K Scott BakerClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, Division of Hematology, Oncology, Blood and Marrow Transplantation, Seattle Children's Hospital, Seattle, USA.ORCID https://orcid.org/0000-0003-3377-1648
Matthew F AbtsDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Sheri BallardDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Jason L FreedmanCellular Therapy and Transplant Section, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0752-2701
Alexander CaraballoCellular Therapy and Transplant Section, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Lisa R YoungDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Pennsylvania, Pennsylvania, USA.
Maureen B JosephsonDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Pennsylvania, Pennsylvania, USA.
Julian L AllenDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Pennsylvania, Pennsylvania, USA.
Devaney M CamburnDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Erin E DohertyBaylor College of Medicine, Texas Children's Hospital, Center for Cell and Gene Therapy, Houston, Texas, USA.
Mashid Sababi AzamianBaylor College of Medicine, Texas Children's Hospital, Center for Cell and Gene Therapy, Houston, Texas, USA.
Martha ArredondoBaylor College of Medicine, Texas Children's Hospital, Center for Cell and Gene Therapy, Houston, Texas, USA.
Manuel Silva-CarmonaDivision of Pediatric Pulmonology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
Leslie E LehmannCenter for Stem Cell Transplantation, Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Wai WongCenter for Stem Cell Transplantation, Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Jonathan M GaffinDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
William McAlpineDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Mona LiDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Samuel B GoldfarbDivision of Pediatric Pulmonary and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Jason C WoodsPediatrics, Blood and Marrow Transplantation & Cellular Therapy Program, University of Minnesota, Minneapolis, Minnesota, USA.
Stella M DaviesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-3137-6647

Funding

TRANSPIRE: A Prospective Cohort Study of Lung Injury After Hematopoietic Stem Cell Transplant in Children.R01HL157392 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Stella Margaret Davies, Samuel Goldfarb · 2021 to 2026
$9.8M
NHLBI NIH HHS R01 HL157392NHLBI NIH HHS R01HL157392
6 · The paper itself

Abstract

backgroundPulmonary complications are a major cause of morbidity and mortality in pediatric and young adult hematopoietic stem cell transplant (HSCT) recipients. The impact of preexisting lung dysfunction on posttransplant outcomes remains understudied.

methodsIn a multi-institutional prospective cohort of 444 patients (≤24 years) undergoing allogeneic HSCT at eight centers, baseline lung function was categorized as normal or abnormal using clinical history, imaging, pulmonary function tests (PFTs), and pulmonologist review. Spirometry and diffusion capacity were assessed at baseline, Day 100, 1 year, and 2 years post-HSCT.

resultsBaseline pulmonary dysfunction was present in 224 patients (50.4%), including impaired spirometry (46.4%), low diffusion capacity (33.8%), and imaging abnormalities (e.g., nodules 19%, interstitial changes 7.9%). These patients had significantly lower median z-scores for forced expiratory volume in 1 s (FEV1) (-2.3 vs. -0.5), forced vital capacity (FVC) (-2.0 vs. -0.3), and diffusion capacity of the lung for carbon monoxide (-2.4 vs. -0.7; all p < 0.001). Lung function impairments persisted through 2 years post-HSCT. FEV1 and FVC remained significantly lower at all time points; FEV1/FVC ratios were similar. Overall survival was lower in the abnormal group (88.4 vs. 95.9%). Seven respiratory-related deaths occurred, including acute respiratory distress syndrome (n = 3), respiratory failure (n = 2), diffuse alveolar hemorrhage (n = 1), and fibrotic lung disease (n = 1).

conclusionsPretransplant pulmonary dysfunction is common and predicts sustained posttransplant impairment and lower survival. Comprehensive baseline assessment may aid in risk stratification and guide early interventions to improve long-term respiratory outcomes in pediatric and young adult HSCT patients. CLINICALTRIALS: GOV IDENTIFIER: NCT04098445.

Indexed as

Hematopoietic Stem Cell TransplantationLung DiseasesAdolescentAdultChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantMalePrevalencePrognosisProspective StudiesRespiratory Function TestsSurvival Rateallogeneic stem cell transplantpediatricPFTpulmonary dysfunction

Identifiers

PMID40692216
PMCPMC12879546

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.