ArticleEndocrine, metabolic & immune disorders drug targets2026
Associations of Anthropometric Indicators with Bone Mineral Density and the Risk of Bone Fractures and Falls: A Large-Scale Genetic Correlation Study.
Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAlthough observational studies have suggested potential associations between Anthropometric Indicators (AIs), Osteoporosis (OP), and bone fractures, the causal links are still scarce. This study aimed to comprehensively evaluate the causal relationships between five AIs and site- and age-specific Bone Mineral Density (BMD), as well as bone fractures and falls.
methodsGenetic exposure data for AIs and outcome data for BMD, bone fractures, and falls were retrieved from various genetic consortia. Genome-wide associations of Single-Nucleotide Polymorphisms (SNPs) were selected as Instrumental Variables (IVs) to infer causal effects in univariable and multivariable Mendelian Randomization (MR) analyses.
resultsThe results of primary univariable MR analyses revealed that a per-unit increase in Hip Circumference (HC) was causally associated with a lower risk of bone fractures (Inverse Variance Weighting (IVW) method: OR = 0.80, 95% CI: 0.74, 0.88; P = 1.73×10 DISCUSSION: Genetic MR analysis establishes HC as an independent protective factor against fractures, resolving prior observational evidence. Limitations include European ancestry bias.
conclusionThis study reveals an independent causal association between HC and a lower risk of bone fractures, suggesting that an appropriate increase in HC is beneficial for the prevention of OP.
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