ArticleAnnals of medicine2025
Extracellular volume fraction quantification by equilibrium contrast-enhanced CT via automated segmentation predicts survival outcomes in bladder cancer: a propensity score-matched study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferation status in rectal cancer: comparison with diffusion kurtosis imaging.Insights into imaging · 2026Article
- Computed tomography-derived extracellular volume fraction is associated with high-grade recurrence in non-muscle-invasive bladder cancer treated with intravesical gemcitabine and docetaxel.BJU international · 2026Article
- CT-derived tumor extracellular volume fraction for predicting recurrence in non-muscle-invasive bladder cancer.Abdominal radiology (New York) · 2026Article
- Dual-energy computed tomography-derived extracellular volume fraction and spectral quantitative parameters for predicting early recurrence after gastrectomy: insights from a multicenter study.Abdominal radiology (New York) · 2026Article
- Predictive value of multivariate models combining CT-based extracellular volume fraction with clinicopathological parameters for preoperative detection of occult lymph node metastasis in gastric cancer.Insights into imaging · 2025Article
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Abstract
backgroundExtracellular volume fraction (ECV) is the unoccupied space or volume of tissue that is not occupied by cells and can be used to assess the growth and invasive behavior of solid tumors. Our study aimed to investigate the ability of extracellular volume fraction in predicting the prognosis of BLCA patients. MATERIALS AND
methodsA retrospective study recruited 319 BLCA patients who underwent surgery. The average CT value was recorded by creating 3D masks of the tumor and blood vessels, which was then used to calculate the preoperative ECV. A propensity score matching (PSM) was performed at a ratio of 1:1 to balance the baseline characteristics between the two groups. Correlations between ECV scores and pathological T stage (whether muscle invasion was present) were determined by using Pearson correlation coefficients. The effects of clinical or pathologic prognostic factors and ECV on recurrence-free survival (RFS), overall survival (OS) were assessed by univariate and multivariate analyses using Cox proportional risk models.
resultsThe 319 patients were divided into two groups, ECV-lower group (
conclusionECV can be used as a noninvasive biomarker to assist in the prognostic assessment of BLCA patients. Higher preoperative ECV indicates a poor prognosis for BLCA and requires aggressive treatment.
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