ReviewBiological psychiatry2026
Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.
Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals.Brain imaging and behavior · 2026Article
- Hippocampus-Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults.Hippocampus · 2026Article
- Article
- Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.Cyborg and bionic systems (Washington, D.C.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Despite centuries of reports documenting both anatomical and functional brain asymmetries, lateralization as an experimental variable remains largely overlooked in preclinical studies focusing on psychiatric disorders. Recent work has identified standard functional and neuroanatomical asymmetries as well as shifts in typical lateralization in the context of diseased states in model organisms. We have collected and examined studies that investigate the contributions of brain areas in the left and/or right hemisphere to the modulation of emotion and affective processing and discuss the contributions of these areas to functional lateralization of psychiatric processing. We focus our review first on describing documentation of anatomical and functional asymmetries that exist in the healthy brain as well as relevant hypotheses for the evolution of lateralization. Then, we dissect the literature to extract evidence for left/right differences and review these studies to highlight evidence for hemispheric lateralization in several psychiatric areas. The specific focus is on the preclinical literature to emphasize the utility of accessible model organisms to study a fundamental feature of normal and abnormal affective neural processing. As momentum continues to shift toward a renewed appreciation of lateralization across species, the study of anatomical and functional asymmetries at the preclinical level will yield novel insights into psychiatric disease in the coming years. Overall, in this review we summarize the existing literature, emphasize remaining questions, and discuss possible mechanisms for shifts in lateralization associated with psychiatric disorders.
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Registered trials
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