Evidence map›Paper›PMID 40691820›Full record

ArticleBMC pediatrics2025

Neonatal meningitis in a full-term neonate due to Streptococcus mitis oralis: a case report.

Sonia Kapoor, Carlos Daniel Varela Chinchilla, Eric J Stern

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sonia KapoorNemours Children's Hospital, Orlando, FL, USA. sonia.kapoor@nemours.org.
Carlos Daniel Varela ChinchillaMedStar Georgetown University Hospital, Washington, DC, USA.
Eric J SternMedStar Georgetown University Hospital, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of neonatal sepsis in the United States of America is 1-2 cases per 1,000 live births. The majority are bacterial infections due to Escherichia coli and Group B Streptococcus. Only a few reported cases due to Streptococcus mitis oralis exist in the literature with limited information regarding management and treatment. CASE PRESENTATION: We report a case of Streptococcus mitis oralis bacteremia and meningitis in a full-term 38 week and 6-day-old female neonate born to a 37-year-old G2P2 mother initially treated with ampicillin and gentamicin for presumed Group B Streptococcus (GBS) sepsis and meningitis, then completing a 14-day treatment course with cefepime.

conclusionClinicians should be aware of S. mitis oralis as it can cause significant illness in both pre-term and term neonates, a population more susceptible to infection. Due to the low incidence of cases, there are no specific guidelines for management of Streptococcus mitis sepsis or meningitis in the newborn. We highlight our clinical decision-making regarding antibiotic selection and treatment duration while focusing on enhancing treatment efficacy based on antimicrobial susceptibilities.

Indexed as

BacteremiaMeningitis, BacterialNeonatal SepsisStreptococcal InfectionsStreptococcus oralisAdultAmpicillinAnti-Bacterial AgentsCephalosporinsFemaleHumansInfant, NewbornAmpicillinAnti-Bacterial AgentsCephalosporinsAntibioticsBacteremiaInfectious diseaseMeningitisNeonatal sepsisStreptococcus mitis oralis

Identifiers

PMID40691820
PMCPMC12278559

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.