Evidence map›Paper›PMID 40691819›Full record

ArticleBMC genomics2025

Identification of key candidate genes and marker metabolites of melanin synthesis in black-bone chicken.

Ziyi Fang, Zhengxiao He, Weifang Yang, Yongli Wang, Yanji Chen, Lilin Men, Richun Cai, Yang Yu, Yaxiong Jia, Guiping Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ziyi Fang *State Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.
Zhengxiao He *State Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.
Weifang YangBeijing General Station of Animal Husbandry, Beijing, 100107, China.
Yongli WangState Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.
Yanji ChenState Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.
Lilin MenState Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.
Richun CaiGuangxi Jinling Agriculture and Animal Husbandry Group Co., LTD, Nanning, 530049, China.
Yang YuGuangxi Jinling Agriculture and Animal Husbandry Group Co., LTD, Nanning, 530049, China.
Yaxiong JiaState Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China. jiayaxiong@caas.cn.
Guiping ZhaoState Key Laboratory of Animal Biotech Breeding, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China. zhaoguiping@caas.cn.

Funding

Government purchase of service contracts 2024-ZF-35the National Key Research and Development Program of China 2023YFD160010303
6 · The paper itself

Abstract

backgroundBlackness and growth traits are regarded as crucial economic traits in black-bone chicken production. In order to meet consumers' demand for black-bone chickens, it is necessary to study the mechanisms of body weight growth and melanin deposition in black-bone chickens. The genetic variations in growth traits, blackness traits, breast muscle transcriptome, and metabolism were compared between the Yanjin black-bone (YJ) chicken group (n = 20) and Jinling Partridge black-bone (JL) chicken group (n = 20). In addition, very high-melanin content (HB) individuals (n = 6) and very low-melanin content individuals (LB) (n = 6) were selected from the JL chicken group to investigate the melanin synthesis mechanism.

resultsComparison between the breast muscle transcriptomes of YJ chickens and JL chickens, as well as between HB and LB of JL chickens, revealed that 81 common differentially expressed genes (DEGs) were significantly enriched in melanosomes, pigment particles, and melanogenesis pathways. Among them, four candidate genes, namely TYRP1, KIT, PRKCB and EDNRB2, may be significantly associated with melanin production in black-bone chicken breast muscle. Also, 2 of the marker metabolites among the 16 common differential metabolites (DMs) identified, namely tetrahydrobiopterin (BH

conclusionOur research presents complex regulatory networks of DEGs and DMs in melanin synthesis pathways. The results establish a basis for raising black-bone chickens with optimal melanin levels and offer a theoretical framework for investigating the mechanisms of melanin formation in these hens.

Indexed as

ChickensMelaninsAnimalsBiomarkersGene Expression ProfilingPigmentationTranscriptomeBiomarkersMelaninsBlack-bone chickenMelanin synthesisMetabolomicsTranscriptomics

Identifiers

PMID40691819
PMCPMC12278494

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