Evidence map›Paper›PMID 40691727›Full record

ArticleEye (London, England)2025

Determinants of visual functions in patients with early and intermediate age-related macular degeneration: the PEONY study.

Fangyao Tang, Shruti Chandra, Manjot K Grewal, Syed Ahmer Raza, Naomi Wijesingha, Livia Faes, Dun Jack Fu, Wei-Shan Tsai, Alicia Lim, Sobha Sivaprasad

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In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fangyao TangInstitute of Ophthalmology, University College London, London, UK.
Shruti ChandraInstitute of Ophthalmology, University College London, London, UK.ORCID http://orcid.org/0000-0002-2634-9775
Manjot K GrewalInstitute of Ophthalmology, University College London, London, UK.
Syed Ahmer RazaNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital National Health Service Foundation Trust, London, UK.
Naomi WijesinghaInstitute of Ophthalmology, University College London, London, UK.ORCID http://orcid.org/0000-0003-0206-1061
Livia FaesInstitute of Ophthalmology, University College London, London, UK.
Dun Jack FuInstitute of Ophthalmology, University College London, London, UK.ORCID http://orcid.org/0000-0003-2852-6912
Wei-Shan TsaiInstitute of Ophthalmology, University College London, London, UK.ORCID http://orcid.org/0000-0001-5945-9316
Alicia LimNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital National Health Service Foundation Trust, London, UK.
Sobha SivaprasadInstitute of Ophthalmology, University College London, London, UK. sobha.sivaprasad@nhs.net.ORCID http://orcid.org/0000-0001-8952-0659

Funding

Fight for Sight UK 1906
6 · The paper itself

Abstract

BACKGROUND/

objectivesAlthough decline in visual functions have been reported in eyes with non-advanced age-related macular degeneration (AMD), it is not known if visual functions in these eyes are influenced by structural changes on optical coherence tomography (OCT). We investigated the association between known OCT changes with photopic and scotopic visual functions. SUBJECTS/

methodsParticipants aged 55 years or over with early or intermediate AMD in at least 1 eye, and controls with healthy maculae and were included. Associations between visual functions and retinal structural changes were investigated using linear regression and survival analysis.

resultsWe found that the presence of refractile drusen and nascent geographic atrophy (nGA) and were associated with poorer best-corrected visual acuity (BCVA), low luminance VA (LLVA), and increased low luminance deficit (LLD) (P < 0.05). In survival analysis, eyes with thicker subfoveal choroidal thickness (SFCT) had a higher hazard rate of rod intercept, suggesting a decreased rod-intercept time (RIT). Eyes with nGA, drusen, refractile drusen, subretinal drusenoid deposits (SDD) have a significantly lower hazard rate of rod intercept (i.e. increased RIT, P < 0.05). Among them, thinner SFCT, drusen, and SDD were identified as independent factors associated with an increased RIT in the final multivariable model (P < 0.05). CONCLUSIONS AND RELEVANCE: Given the associations between visual functions with outer retinal layers thickness and presence of established precursors of progression to advanced AMD, our findings serve as a strong foundation for future investigations into the relationships between retinal phenotypes and functional changes.

Indexed as

Macular DegenerationVisual AcuityAgedAged, 80 and overColor VisionFemaleGeographic AtrophyHumansMaleMiddle AgedRetinal DrusenTomography, Optical Coherence

Identifiers

PMID40691727
PMCPMC12446449

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.