Evidence map›Paper›PMID 40691661›Full record

ArticleMaternal and child health journal2025

Assessing Change in Medical Management of Early Pregnancy Loss before and after Implementation of a Learning Collaborative for Initiation of Mifepristone Use.

Catherine Hennessey, Lisa Wu, Lauren Harriett, Kathryn Nutting, Ashley McHugh, Julie Chor, Diane Lauderdale, Debra Stulberg

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Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Catherine HennesseyDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th Street, J-130, New York, NY, 10065, USA. cah4023@med.cornell.edu.ORCID http://orcid.org/0000-0001-7871-5151
Lisa WuDepartment of Obstetrics and Gynecology, MedStar Washington Hospital Center, 110 Irving Street NW, Suite 5B-63, Washington, D.C, 20010, USA.
Lauren HarriettDepartment of Family Medicine, University of Chicago, 5841 S. Maryland Ave MC, 7110, Chicago, IL, 60637, USA.
Kathryn NuttingOhio State University Community and Family Medicine, 543 Taylor Ave, Columbus, OH, 43203, USA.
Ashley McHughDepartment of Family Medicine, University of Chicago, 5841 S. Maryland Ave MC, 7110, Chicago, IL, 60637, USA.
Julie ChorDepartment of Obstetrics and Gynecology, University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, Illinois, 60637, USA.
Diane LauderdaleDepartment of Public Health Sciences, University of Chicago, 5841 S. Maryland Ave, MC 2000, Chicago, IL, 60637, USA.
Debra StulbergDepartment of Family Medicine, University of Chicago, 5841 S. Maryland Ave MC, 7110, Chicago, IL, 60637, USA.

Funding

Argosy Foundation Argosy FoundationCollaborative for Gender + Reproductive Equity Collaborative for Gender + Reproductive EquityIrving Harris Foundation Irving Harris FoundationLisa & Douglas Goldman Fund Lisa & Douglas Goldman FundSociety of Family Planning Society of Family Planning
6 · The paper itself

Abstract

objectivesExPAND Mifepristone is a one-year learning collaborative providing support for mifepristone provision in primary care for early pregnancy loss (EPL) or abortion. This study measured change in prevalence of medical management of EPL at a federally qualified health center (FQHC) that participated in ExPAND Mifepristone's pilot year. Secondary objectives were to describe changes in referral patterns and medication choice for EPL.

methodsTo quantify changes in medical management of EPL, we conducted a retrospective data query using International Classification of Diseases-10 codes during two time periods: pre-implementation (January 1, 2019 - February 29, 2020) and post-implementation (August 1, 2021 - June 30, 2022). Manual chart review was used to assess change in referral patterns for EPL.

resultsThere were 193 patients with EPL in the pre-implementation period and 115 post-implementation. Pre-implementation, 8.3% (n=16) of EPL patients received medical management versus 15.7% (n=18) post-implementation (p=0.046). The percentage of all patients with EPL who received misoprostol alone was 8.3% pre- and 8.7% (p=0.91) post-implementation. Treatment with mifepristone plus misoprostol increased to 44.4%. EPL referrals to Obstetrics/Gynecology (OB/GYN) decreased from 14.0% to 1.7% (p=0.001). The most frequent reason for referral was procedural management.

conclusionAfter participation in ExPAND Mifepristone, there was an increase in medical management for EPL by PCPs and referrals to OB/GYN declined. ExPAND Mifepristone can help facilitate PCP use of mifepristone plus misoprostol for medical management of EPL. KEY WORDS: Primary Care, Early Pregnancy Loss, Mifepristone, Women's Health, Referral.

Indexed as

Abortifacient Agents, SteroidalAbortion, SpontaneousMifepristoneAbortion, InducedAdultFemaleHumansMisoprostolPregnancyPrimary Health CareReferral and ConsultationRetrospective StudiesAbortifacient Agents, SteroidalMifepristoneMisoprostolEarly Pregnancy LossMifepristoneMisoprostolPrimary CareWomen’s Health

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.