Evidence map›Paper›PMID 40691648›Full record

ArticleVeterinary research2025

Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.

Dengfu Li, Haixia Li, Zhu Wang, Yuchen Huang, Chenchong Zhao, Hongxia Zhang, Yanan Zhao, Naihui Zhu, Xirong Tang, Yaping Jin and 1 more

Abstract read
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Infection and immunity · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dengfu LiCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Haixia LiCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Zhu WangCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Yuchen HuangCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Chenchong ZhaoCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Hongxia ZhangCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Yanan ZhaoCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Naihui ZhuCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Xirong TangCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Yaping JinCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China. yapingjin@163.com.
Dong ZhouCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China. zhoudong1949@nwafu.edu.cn.ORCID http://orcid.org/0000-0001-8909-0249

Funding

national Key Research and Development Program of China 2023YFD1801100National Natural Science Foundation of China 31702310
6 · The paper itself

Abstract

Trueperella pyogenes is an opportunistic pathogen frequently associated with bovine endometritis, yet the mechanisms by which it induces uterine inflammation remain incompletely understood. In this study, we investigated the effects of T. pyogenes and its membrane vesicles (MVs) on bovine endometrial epithelial cells (BEECs) and explored the underlying inflammatory pathways involved. Bovine endometrial epithelial cells (BEECs) were treated with T. pyogenes (MOI = 100) or MVs at various concentrations (1 × 10

Indexed as

ActinomycetaceaeActinomycetales InfectionsCattle DiseasesEndometriumEpithelial CellsMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionAnimalsCattleCytokinesEndometritisFemaleTime FactorsCytokinesMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 Proteinendometritismembrane vesiclesMyD88/NF-κBNLRP3 inflammasomeTrueperella pyogenes

Identifiers

PMID40691648
PMCPMC12281939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.