Evidence map›Paper›PMID 40691625›Full record

ArticleJournal of neuroengineering and rehabilitation2025

Transcutaneous auricular vagus nerve stimulation enhances structural and functional remodeling in sensorimotor networks following intracerebral hemorrhage in rats.

Jun Zhang, Zengyu Zhang, Lichao Wei, Dewen Ru, Meihua Wang, Pengfei Fu, Weijian Yang, Gang Wu, Lei Yang, Caihua Xi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jun Zhang *Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Zengyu Zhang *Department of Neurology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Lichao WeiDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Dewen RuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Meihua WangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Pengfei FuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Weijian YangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Gang WuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Lei YangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Caihua XiDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Xiangru YeDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Yuwen ZhangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. yuwenzhang@fudan.edu.cn.
He WangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. hewang@fudan.edu.cn.
Jin HuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. hujin@fudan.edu.cn.
Qiang YuanDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. yuanqiang@huashan.org.cn.

Funding

Academician Innovation Platform Fund of Hainan Province YSPTZX202033National Natural Science Foundation of China 82171382National Natural Science Foundation of China 82471407Shanghai Shenkang Hospital Development Center-Municipal Hospital Diagnosis and Treatment Technology Promotion and Optimization Management Project SHDC22023224
6 · The paper itself

Abstract

backgroundIntracerebral hemorrhage (ICH) leads to severe neurological deficits by disrupting brain structure and function, particularly in the sensorimotor cortex. Effective interventions to promote post-ICH brain remodeling remain limited. This study investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on structural and functional remodeling in the sensorimotor networks of rats with ICH, using multi-scale analyses spanning micro-, meso-, and macro-levels.

methodsA rat model of left basal ganglia ICH was established, followed by taVNS intervention. Structural remodeling was assessed through histology, immunofluorescence, and transmission electron microscopy. Functional remodeling was evaluated using fractional amplitude of low-frequency fluctuations (fALFF) and degree centrality (DC) analyses.

resultstaVNS enhanced myelin repair and axonal remodeling, indicated by increased myelin basic protein (MBP) expression, reduced dephosphorylated neurofilament protein (SMI-32), and partial restoration of synaptic ultrastructure. Functional imaging showed significant longitudinal increases in zfALFF and zDC values in sensorimotor regions, including the primary and secondary motor cortices, which negatively correlated with modified neurological severity scores (mNSS).

conclusiontaVNS promotes structural and functional remodeling in the sensorimotor cortex after ICH, offering a potential therapeutic strategy for neurological recovery.

Indexed as

Cerebral HemorrhageNeuronal PlasticitySensorimotor CortexTranscutaneous Electric Nerve StimulationVagus Nerve StimulationAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyBrain remodelingIntracerebral hemorrhageNeuroplasticitySensorimotor networksTaVNS

Identifiers

PMID40691625
PMCPMC12278549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.