Evidence map›Paper›PMID 40691621›Full record

ArticleStem cell research & therapy2025

Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice.

Narae Hwang, Gu Li, Ekaterina Murzin, Cassidy J Mays, James A Lederer, Xiaoli Liu, Mark A Perrella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Narae HwangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA.
Gu LiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA.
Ekaterina MurzinDepartment of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cassidy J MaysDivision of Pediatric Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
James A LedererDepartment of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaoli Liu *Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA.
Mark A Perrella *Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA. mperrella@bwh.harvard.edu.

Funding

Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonistsU01AI138318 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LEDERER, JAMES A., PERRELLA, MARK A · 2018 to 2022
$3.1M
Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial InfectionR01GM136804 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A · 2020 to 2023
$1.4M
Cellular Therapy for Sepsis and Lung InjuryR35GM161257 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Mark A PERRELLA · 2026 to 2026
$446k
NIAID NIH HHS U01 AI138318NIGMS NIH HHS R01 GM136804NIGMS NIH HHS R35 GM161257NIH HHS 5R01GM136804NIH HHS 5U01AI138318
6 · The paper itself

Abstract

backgroundSepsis is a complex and life-threatening disease process related to a systemic response to severe infection. Due to the challenges of treating patients with sepsis, new therapies are being investigated, including cell-based approaches. Trophoblast stem cells (TSCs) are immune privileged cells with immunomodulatory properties. Thus, we proposed that TSCs may be beneficial in experimental models of sepsis to regulate the immune response and curtail organ injury.

methodsSepsis was induced by experimental models in mice; cecal ligation and puncture (CLP) and lung infection with Streptococcus (S.) pneumoniae. TSCs were isolated from the chorionic villi of human (h) term placentas, and from mouse (m) placentas using anti-CD117 MicroBeads, and were administered intravenously 6 h after CLP or S. pneumoniae infection. We assessed mortality, bacterial clearance, organ injury, inflammatory response, and production of cytokines and chemokines.

resultsCD117

conclusionsCD117

Indexed as

PneumoniaSepsisStem CellsStem Cell TransplantationTrophoblastsAnimalsCytokinesDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLPregnancyStreptococcus pneumoniaeCytokinesAcute organ injuryBacterial clearanceInflammationSepsisTrophoblast stem cells

Identifiers

PMID40691621
PMCPMC12282005

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.