ArticleBMC cancer2025
The impact of stratified management of Ki-67 on the prognosis of small-cell lung cancer.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Development and validation of a nomogram for predicting overall survival in small cell lung cancer: a multicenter analysis integrating multimodal therapy and molecular pathology.Translational lung cancer research · 2026Article
- Evaluation of nomogram prediction model for postoperative deep vein thrombosis in patients with non-small cell lung cancer.Translational cancer research · 2025Article
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Abstract
objectiveThe Ki-67 protein is frequently employed in pathological immunohistochemistry to indicate cell proliferation activity. The principal aim of this study was to examine the impact of stratified management of Ki-67 on the clinicopathological characteristics and prognosis of patients with small-cell lung cancer (SCLC).
methodsA total of 175 patients with SCLC who underwent surgical treatment were included in the study, with available data on the results of postoperative immunohistochemistry of the Ki-67 protein. A retrospective analysis was conducted to investigate the correlation between the protein and various clinicopathological features of SCLC, as well as its impact on survival.
resultsThe cut-off value for the Ki-67 level was determined to be 75% through receiver operating characteristic (ROC) analysis. An elevated Ki-67 level was found to be associated with preoperative chemotherapy (χ2 = 4.980, P = 0.028), preoperative radiotherapy (χ2 = 4.600, P = 0.032), T stage (χ2 = 4.173, P = 0.041), TNM staging (χ2 = 10.472, P = 0.005), and lymph node involvement (χ2 = 16.721, P < 0.0001). The results of the survival analysis indicated that patients with SCLC exhibiting high levels of Ki-67 had a poorer prognosis than those with low Ki-67 levels (P = 0.0004). This was particularly evident in patients aged 60 years or older (P = 0.034), in males (P = 0.046), smoking for a minimum of 30 years (P < 0.001), advanced T staging (T3 + T4) (P = 0.031), lymph node involvement (P = 0.038), and TNM staging (P = 0.015), were associated with poorer outcomes. The univariate Cox regression analysis indicated that exposure to tobacco consumption (P = 0.040), pathologic T stage (P = 0.047), lymph node metastasis (P = 0.002), TNM staging [Stage I vs. II (P = 0.016), Stage I vs. III (P = 0.003)], and Ki-67 positive rate (P < 0.001) were the factors related to prognosis in SCLC. The results of the multivariate regression analysis indicated that T stage(HR: 1.519, 95% CI: 1.116-2.015, P = 0.022), TNM staging[Stage I vs. III (HR: 2.310, 95% CI: 1.320-4.040, P < 0.001)], and Ki-67 expression(HR: 1.405, 95% CI: 1.025-1.810, P < 0.001) was identified as an additional risk factor for SCLC-related mortality.
conclusionIn summary, the Ki-67 protein is not only strongly associated with the malignant characteristics of SCLC, but also the stratification of Ki-67 has significant implications for the treatment and prognosis of patients with small-cell lung cancer. CLINICAL TRIAL NUMBER: Not applicable.
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