Evidence map›Paper›PMID 40691487›Full record

Observational studyScientific reports2025

Correlation between dietary salt intake and renal outcomes related to calcineurin inhibitor nephrotoxicity in kidney transplant recipients.

Satoru Sanada, Saki Katano, Kengo Asami, Hiroyuki Kumata, Satoshi Sekiguchi, Mitsuhiro Sato

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Satoru SanadaDivision of Nephrology, Japan Community Health Care Organization Sendai Hospital, 2-1-1, Murasakiyama, Izumi, Sendai, Miyagi, Japan. satsanada@sendai-kidney.jp.
Saki KatanoDivision of Nephrology, Japan Community Health Care Organization Sendai Hospital, 2-1-1, Murasakiyama, Izumi, Sendai, Miyagi, Japan.
Kengo AsamiDivision of Surgery, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.
Hiroyuki KumataDivision of Surgery, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.
Satoshi SekiguchiDivision of Surgery, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.
Mitsuhiro SatoDivision of Nephrology, Japan Community Health Care Organization Sendai Hospital, 2-1-1, Murasakiyama, Izumi, Sendai, Miyagi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tonicity-responsive enhancer binding protein (TonEBP) protects kidney tubular cells against hypertonicity. Calcineurin inhibitors (CNI) are known to suppress TonEBP by hampering nuclear translocation. Moreover, sodium inversely activates TonEBP. We investigated whether CNI-induced nephrotoxicity in transplant recipients could be due to impaired TonEBP activity, and whether sodium restriction exacerbates the intoxication. Immunohistochemical analysis using biopsy specimens from 128 patients revealed that TonEBP was mainly located in the cytoplasm in cases of CNI nephrotoxicity, while it showed nuclear-cytoplasmic staining in cases of rejection or interstitial fibrosis and tubular atrophy. This suggests that TonEBP transactivation is limited in CNI nephrotoxicity. A retrospective observational analysis of 308 kidney transplant recipients at our institute between 1984 and 2018 showed a positive correlation between dietary salt intake and eGFR slope. A low-salt diet is linked to a rapid annual decline in eGFR, with adjusted odds ratios of 2.40 and a 95% confidence interval of 1.18-4.90. These findings suggest that the recommended salt intake for kidney transplant recipients may require reassessment.

Indexed as

Calcineurin InhibitorsKidneyKidney TransplantationSodium Chloride, DietaryAdultAgedFemaleGlomerular Filtration RateGraft RejectionHumansMaleMiddle AgedRetrospective StudiesTransplant RecipientsCalcineurin InhibitorsSodium Chloride, DietaryCalcineurin inhibitor nephrotoxicityGraft survivalRenal transplantationSalt restrictionTonicity responsive enhancer binding protein

Identifiers

PMID40691487
PMCPMC12280067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.