Evidence map›Paper›PMID 40691451›Full record

ArticleScientific reports2025

A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch.

Darya Pavlenko, Hirotake Ishida, Anika Markan, Tasuku Akiyama

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Darya PavlenkoDr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB2063, Miami, FL, USA.
Hirotake IshidaDr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB2063, Miami, FL, USA.
Anika MarkanDr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB2063, Miami, FL, USA.
Tasuku AkiyamaDr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB2063, Miami, FL, USA. takiyama@miami.edu.

Funding

The neuronal circuits of affective itchR01AR074062 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AKIYAMA, TASUKU · 2018 to 2022
$1.7M
NIAMS NIH HHS R01 AR074062NIAMS NIH HHS R01AR074062Stanley Glaser Foundation UM SJG 2019-18
6 · The paper itself

Abstract

The parabrachial nucleus (PBN) plays a crucial role in transmitting itch and affective pain signals to the brain regions such as the central amygdala (CeA). While CGRP

Indexed as

Central Amygdaloid NucleusParabrachial NucleusPruritusAnimalsAnxietyBehavior, AnimalCalcitonin Gene-Related PeptideDisease Models, AnimalMaleMiceMice, Inbred C57BLNeuronsOptogeneticsSerotoninCalcitonin Gene-Related PeptideSerotoninCGRPOptogeneticsPainPruritusScratching

Identifiers

PMID40691451
PMCPMC12280202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.