Evidence map›Paper›PMID 40691437›Full record

ArticleTranslational psychiatry2025

Sex-specific cortical networks drive social behavior differences in an autism spectrum disorder model.

Mariana Lapo Pais, José Sereno, Vanessa A Tomé, Carla Fonseca, Camila Seco, Inês Ribeiro, João Martins, Ana Fortuna, Antero Abrunhosa, Luísa Pinto and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariana Lapo PaisUniversity of Coimbra, Faculty of Sciences and Technology, Coimbra, Portugal.ORCID http://orcid.org/0000-0003-2082-0842
José SerenoUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.
Vanessa A ToméUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.
Carla FonsecaUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.ORCID http://orcid.org/0000-0002-3320-9658
Camila SecoUniversity of Coimbra, Faculty of Sciences and Technology, Coimbra, Portugal.
Inês RibeiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
João MartinsUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.
Ana FortunaUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.
Antero AbrunhosaUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.ORCID http://orcid.org/0000-0002-4145-854X
Luísa PintoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID http://orcid.org/0000-0002-7724-0446
Miguel Castelo-BrancoUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.ORCID http://orcid.org/0000-0003-4364-6373
Joana GonçalvesUniversity of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal. jgoncalves@icnas.uc.pt.ORCID http://orcid.org/0000-0002-5854-8664

Funding

Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) 2020.06582.BDMinistry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) 2021.06135.BDMinistry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) 2022.01066.PTDCMinistry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) UIDP&B/04950/2020
6 · The paper itself

Abstract

Social behavior is highly sensitive to brain network dysfunction caused by neuropsychiatric conditions like autism spectrum disorders (ASDs). Some studies suggest that autistic females show fewer social skill impairments than autistic males. However, the relationship between sex differences in social behavior and sexually dimorphic brain neurophysiology in ASD remains unclear. We hypothesize that sex-specific changes in cortical neurophysiology drive the sexual dimorphism observed in social behavior for ASD. To test this, we used male and female Tsc2

Indexed as

Autism Spectrum DisorderCerebral CortexSex CharacteristicsSocial BehaviorAmygdalaAnimalsBehavior, AnimalDisease Models, AnimalFemaleHippocampusMaleMiceMice, TransgenicNeuronsReceptor, Serotonin, 5-HT1ASerotoninReceptor, Serotonin, 5-HT1ASerotoninTuberous Sclerosis Complex 2 Protein

Identifiers

PMID40691437
PMCPMC12279983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.