ArticleNature communications2025
Transcriptomics and trans-organellar complementation reveal limited signaling of 12-cis-oxo-phytodienoic acid during early wound response in Arabidopsis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Hormone-metabolism crosstalk in plants: an integrated signaling network coordinating growth and stress adaptation.Plant signaling & behavior · 2026Review
- Molecular Mechanisms and Network Integration of Oxylipin Signaling in Plant Abiotic Stress Tolerance.International journal of molecular sciences · 2026Review
- Size of chloroplasts in Arabidopsis mesophyll cells affects jasmonate biosynthesis.Plant biology (Stuttgart, Germany) · 2026Article
- The OPR gene family: bioinformatics characterization and functional implications for soybean seed deterioration.Frontiers in plant science · 2026Article
- Interaction with CYP20-3 limits OPDA flux into jasmonate biosynthesis in wounded leaves of arabidopsis grown at eCOFrontiers in plant science · 2026Article
- HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato.Nature communications · 2025Article
- Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana.Nature communications · 2025Article
- Phyto-Oxylipins as Key Regulators of Plant Resilience to Abiotic and Biotic Stress.Physiologia plantarumReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
12-cis-oxo-phytodienoic acid (OPDA), a precursor of jasmonoyl-isoleucine (JA-Ile), is known to have distinct signaling roles in Arabidopsis, as shown in studies using the opr3 mutant, which lacks OPDA REDUCTASE3 (OPR3). This mutant, however, accumulates low levels of JA-Ile through an OPR2-mediated bypass. To investigate OPDA signaling, the wound-induced transcriptome of the opr2opr3 mutant is compared to that of wild-type and allene oxide synthase mutant. Endogenous OPDA shows no unique transcriptional signature under control or wounding conditions, and previously identified OPDA-responsive genes are wound-induced independently of OPDA. Applying OPDA to opr2opr3 triggers a distinct response suggesting compartmentalization of endogenously formed OPDA. Trans-organellar complementation reveals that expression of OPR3 or OPR2 in opr2opr3 restores JA-Ile production regardless of localization, whereas mitochondrial targeted OPR1 exhibiting low OPDA/4,5-ddh-JA conversion activity does not. Our findings show that OPDA primarily serves as a JA precursor with limited independent signaling functions in the early wound response.
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Registered trials
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