Evidence map›Paper›PMID 40691405›Full record

SynthesisNature genetics2025

A contextual genomic perspective on physical activity and its relationship to health, well being and illness.

Marco Galimberti, Daniel F Levey, Joseph D Deak, Keyrun Adhikari, Cassie Overstreet, Priya Gupta, Rachana Nitin, Hang Zhou, Nicole J Lake, Kelly M Harrington and 6 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Marco GalimbertiVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0001-6052-156X
Daniel F LeveyVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0001-8431-9569
Joseph D DeakVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-0540-6080
Keyrun AdhikariVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0001-9129-1699
Cassie OverstreetVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Priya GuptaVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Rachana NitinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hang ZhouVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Nicole J LakeDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-4103-6387
Kelly M HarringtonDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Luc DjousseMillion Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.
Lea K DavisDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
VA Million Veteran Program
J Michael GazianoMillion Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.
Murray B SteinVA San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Joel GelernterVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859

Funding

7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M
Genetics of Alcohol Dependence in African Americans: RecruitmentR01AA026364 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2018 to 2022
$2.0M
BLRD VA IK2 BX005058CSRD VA I01 CX001849NIAAA NIH HHS R01 AA026364NIDA NIH HHS R01 DA054869
6 · The paper itself

Abstract

Physical activity (PA) is one of the most fundamental traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program, we conducted genetic analyses of leisure, work and home-time PA. For leisure, we included 189,812 individuals of European ancestry (SNP-based heritability (h

Indexed as

African PeopleEuropean PeopleExerciseHispanic or LatinoAgedCentral American PeopleCOVID-19FemaleGenome-Wide Association StudyGenomicsHealth StatusHumansLeisure ActivitiesMaleMendelian Randomization AnalysisMiddle Aged

Identifiers

PMID40691405
PMCPMC12339386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.