ArticleNature genetics2025
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma.
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Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Review
- A USP8-targeting nanoamplifier synergizes with radiotherapy to remodel the immunosuppressive tumor microenvironment in lung cancer.Materials today. Bio · 2026Article
- SDC1Gut · 2026Article
- Chemotherapy-Activated GSK3β-DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell transcriptomics and functional validation reveal a TUBB4B-associated malignant epithelial state in nasopharyngeal carcinoma.Journal of translational medicine · 2026Article
- Viral persistence and host-state remodeling in virus-associated cancers.Archives of microbiology · 2026Review
- Spontaneous Intracellular Formation of Covalent Organic Frameworks via Enzyme-Initiated Cascade Reactions to Boost Cancer Radiotherapy.Journal of the American Chemical Society · 2026Article
- Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026Review
- Advances in the Research of Nasopharyngeal Carcinoma: A Perspective.Cancer innovation · 2026Review
- HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell and spatial transcriptomics reveal that THBS1 induces radiation resistance in TNBC through the interaction between myCAF and TOPBP1⁺ tumor cells.Journal of translational medicine · 2026Article
- Interpretable and scalable spatial gene set activity analysis with GESSO uncovers functional tissue architecture.bioRxiv : the preprint server for biology · 2026Article
- Ubiquitin choreography in nasopharyngeal carcinoma: USP18 scaffolds radioresistance.Cell death and differentiation · 2026Article
- FineST: contrastive learning integrates histology and spatial transcriptomics for nuclei-resolved ligand-receptor analysis.Nature communications · 2026Article
- Harnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy.Cell death discovery · 2026Review
- Article
- Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy.Signal transduction and targeted therapy · 2026Article
- Extracellular Vesicles: A Multidimensional Role in the Occurrence and Development of Nasopharyngeal Carcinoma.Biomolecules · 2026Review
- Nasopharyngeal Carcinoma at the Virology Precision Oncology Nexus: Decoding Molecular Alterations for Early Intervention and Therapeutic Innovation.Biomolecules · 2026Review
- Current Perspectives on Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2026Review
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Authors and funding
23 authors.
Rui You *Nasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China. your5@mail.sysu.edu.cn.ORCID http://orcid.org/0009-0000-7786-9749
Qunlun Shen *State Key Laboratory of Mathematical Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, The People's Republic of China.ORCID http://orcid.org/0000-0002-7149-6803
Chao Lin *Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Kangning Dong *School of Mathematics, Renmin University of China, Beijing, The People's Republic of China.
Xiao Liu *Nasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China.
Hanshi Xu *Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Wanming HuState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Yulong XieDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Ruoqi XieDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Xiaoyi SongNasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China.
Chunliu HuangNasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China.
Jinhui WuState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Tao YuState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Huifeng LiDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Zining WangState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.ORCID http://orcid.org/0000-0002-0087-2453
Keming ChenState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Xiong ZouDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Peiyu HuangDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Yijun HuaDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China.
Youping LiuNasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China. liuyp78@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-0738-3334
Tianliang XiaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, The People's Republic of China. xiatl@sysucc.org.cn.ORCID http://orcid.org/0009-0002-3369-8612
Shihua ZhangState Key Laboratory of Mathematical Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, The People's Republic of China. zsh@amss.ac.cn.ORCID http://orcid.org/0000-0003-0192-7118
Mingyuan ChenNasopharyngeal Cancer Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, The People's Republic of China. chmingy@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-4793-0902
Funding
Guangzhou Science and Technology Program key projects 202103010001Guangzhou Science and Technology Program key projects 2023A04J1760National Natural Science Foundation of China (National Science Foundation of China) 82230034National Natural Science Foundation of China (National Science Foundation of China) 82373407
Abstract
Radiotherapy resistance and immune evasion are prominent features of recurrent nasopharyngeal carcinoma (rNPC). However, their mechanisms remain incompletely understood. Here, we conducted single-cell and spatial transcriptomics analysis of 39 tumors from 24 patients to reveal the microenvironmental differences between primary and rNPC. Specific MCAM
Indexed as
Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm Recurrence, LocalRadiation ToleranceTranscriptomeTumor EscapeCancer-Associated FibroblastsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmune EvasionSingle-Cell AnalysisTumor Microenvironment
Identifiers
PMID
40691404What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.