Evidence map›Paper›PMID 40691389›Full record

ArticleJournal of cardiovascular translational research2025

The Diagnostic Significance of Circulating Eicosanoid in Patients with Hypertrophic Cardiomyopathy.

Yue Zhang, Xinyu Liu, Zhongze Zhang, Weiyan Sun, Wenjing Yue, Le Liu, Yi Zhu, Xu Zhang, Hong Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue ZhangTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Xinyu LiuTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Zhongze ZhangTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Weiyan SunTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Wenjing YueTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Le LiuTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Yi ZhuTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Xu ZhangTianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. xuzhang@tmu.edu.cn.
Hong WangDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorder, Wuhan, Hubei, China. alextowh@163.com.ORCID 0009-0009-6602-4025

Funding

National Natural Science Foundation 82370295
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases. Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were profiled by LC-MS in a cohort of 78 healthy individuals and 73 patients diagnosed with HCM. Our findings reveal HCM patients exhibit downregulation of various eicosanoids, including AA, 5,6-DHET, 12-HETE, LXA4, EPA, etc. Notably, the combined predictive model incorporating 12-HETE and EPA demonstrates significant diagnostic value for HCM. Additionally, ten closely related metabolites showed significant positive correlations within the metabolic network graph. Eicosanoids such as 17,18-EEQ, LXA4, and 13-oxo-ODE exhibit significant negative correlations with plasma concentrations of hs-CRP and NT-proBNP in patients. Alterations in eicosanoid metabolism may be implicated in the pathophysiological processes underlying HCM.

Indexed as

Cardiomyopathy, HypertrophicEicosanoidsMetabolomicsAdultAgedBiomarkersCase-Control StudiesChromatography, LiquidFemaleHumansMaleMiddle AgedPredictive Value of TestsBiomarkersEicosanoidsBiomarkersEicosanoidsHypertrophic cardiomyopathyMetabolomics

Identifiers

PMID40691389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.