Evidence map›Paper›PMID 40691388›Full record

ArticleJournal of cardiovascular translational research2025

Normoxemic Extracorporeal Membrane Oxygenation Reduces Infarct Size and Preserves Mitochondrial Integrity in Preclinical Models of Acute Myocardial Infarction.

Shreyas Bhave, Lija Swain, Lara Reyelt, Xiaoying Qiao, Tejasvi Aryaputra, Kay Everett, Kevin John, Isabella Berry, Arik Stolyaranov, Elena Mahmoudi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shreyas BhaveThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Lija SwainThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Lara ReyeltThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Xiaoying QiaoThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Tejasvi AryaputraThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Kay EverettThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Kevin JohnThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Isabella BerryThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Arik StolyaranovThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Elena MahmoudiThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Michael ChinThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.
Navin K KapurThe Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA. Nkapur@tuftsmedicalcenter.org.ORCID 0000-0002-8302-6796

Funding

New Approaches to Mitigate Left Ventricular Injury with VA-ECMO in Acute Myocardial InfarctionR01HL159089 · NHLBI · TUFTS MEDICAL CENTER · PI KAPUR, NAVIN KUMAR · 2021 to 2024
$3.4M
Mechanical Unloading and Delayed Reperfusion Promotes Myocardial Recovery after Acute Myocardial InfarctionR01HL139785 · NHLBI · TUFTS MEDICAL CENTER · PI KAPUR, NAVIN KUMAR · 2018 to 2021
$2.9M
American Heart Association 938033American Heart Association-American Stroke Association 938033NHLBI NIH HHS R01 HL139785NHLBI NIH HHS R01HL139785NHLBI NIH HHS R01 HL159089NHLBI NIH HHS R01HL159089
6 · The paper itself

Abstract

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides cardiopulmonary support during the critical care. Despite its exponential use over last few decades, clinical studies suggest that it does not improve infarct size and mortality in patients suffering from cardiogenic shock after the acute myocardial infarction (AMI). The effect of hyperoxygenated blood under high pressure on the poor outcomes associated with VA-ECMO have not been tested. In this study we tested the hypothesis whether normoxemic oxygenation of blood during provides protection against VA-ECMO associated cardiac damage using a swine model of AMI. Our results indicate that normoxemic VA-ECMO (PaO2 < 200 mmHg), reduces infarct size, activates pro-survival RISK pathway and furthermore preserves mitochondrial structure and function as compared to hyperoxygenated VA-ECMO (PaO2 > 200 mmHg) in ischemia-reperfusion injury. In absence of conclusive clinical trials testing the effect of VA-ECMO blood oxygenation on the patients' outcomes, our findings provide new mechanistic insight into the myocardial effects of VA-ECMO.

Indexed as

Extracorporeal Membrane OxygenationMitochondria, HeartMyocardial InfarctionMyocardial Reperfusion InjuryOxygenAnimalsDisease Models, AnimalMaleSus scrofaTime FactorsOxygenAcute myocardial infarctionCirculatory supportHeart failureMitochondrial disease

Identifiers

PMID40691388
PMCPMC13221399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.