Evidence map›Paper›PMID 40691371›Full record

ArticleNeurochemical research2025

Extracellular Matrix Proteins Differentiate Postnatal Mouse Retina Neurospheres into Neurons or Glia Profiles.

Orquidia Guadalupe Méndez-Flores, Anna Carolina Rego Costa, Andrey Fabiano Lourenço de Aguiar, Yolanda Paes-Colli, Cláudia Maria Batista, Victor T Ribeiro-Resende, Arturo Ortega, Ricardo A de Melo Reis

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Orquidia Guadalupe Méndez-FloresLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0000-0003-2768-0002
Anna Carolina Rego CostaLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0009-0009-6337-2665
Andrey Fabiano Lourenço de AguiarLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0000-0003-3914-4549
Yolanda Paes-ColliLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0000-0001-9275-1175
Cláudia Maria BatistaLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0000-0001-7744-5372
Victor T Ribeiro-ResendeLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.ORCID http://orcid.org/0000-0003-1135-4149
Arturo OrtegaDepartment of Toxicology, Cinvestav, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-9594-8114
Ricardo A de Melo ReisLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil. ramreis@biof.ufrj.br.ORCID http://orcid.org/0000-0001-9689-4085

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías PhD Fellowship 290749Conselho Nacional de Desenvolvimento Científico e Tecnológico 426342/2018-6; PQ 2 FellowshipConselho Nacional de Desenvolvimento Científico e Tecnológico PhD FellowshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior PhD FellowshipFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro No E-26/202.668/2018
6 · The paper itself

Abstract

The mammalian retinal progenitor cells (RPC) exit the cell cycle through signaling of intrinsic and extrinsic factors and give rise to several types of neurons and Müller glia, following an organized spatial-temporal pattern. Extracellular matrix (ECM) plays an important role in retinal development, influencing RPC proliferation and differentiation into pro-gliogenic and/or neurogenic phenotypes. Here, we investigated how four different ECM constituents, fibronectin, vitronectin, collagen type IV and laminin-1 (α1β1γ1), added on coverslips previously treated with 10 µg/mL poly-L-lysine, could impact differentiation of retinal neurospheres generated with epidermal growth factor (EGF) 20 ng/mL and cultivated for four days. Progenitors (activated by muscimol, a GABA

Indexed as

Cell DifferentiationExtracellular Matrix ProteinsNeurogliaNeuronsRetinaAnimalsAnimals, NewbornCells, CulturedExtracellular MatrixLamininMiceMice, Inbred C57BLExtracellular Matrix ProteinsLamininCalciumCollagen type IVFibronectinLamininNeuron-gliaRetinaVitronectin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.