Evidence map›Paper›PMID 40691340›Full record

ArticleTropical animal health and production2025

Transcriptional variation of meat quality marker genes in different age and sex groups of Balkhi breed sheep.

Muhammad Farooq Akhtar, Rajwali Khan, Syed Muhammad Suhail, Abdur Rehman, Ijaz Ahmad, Iftikhar Ahmad, Farhan Anwar Khan, Faraz Ahmad, Athar Rehman, Muhammad Ayaz and 2 more

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Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

12 authors.

Muhammad Farooq Akhtar *Department of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Rajwali Khan *Department of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan. rajwalikhan@aup.edu.pk.ORCID http://orcid.org/0000-0001-5191-3457
Syed Muhammad SuhailDepartment of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Abdur RehmanFaculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, Peshawar, 25130, Pakistan.
Ijaz AhmadFaculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, Peshawar, 25130, Pakistan.
Iftikhar AhmadDepartment of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Farhan Anwar KhanFaculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, Peshawar, 25130, Pakistan.
Faraz AhmadDepartment of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Athar RehmanDepartment of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Muhammad AyazDepartment of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan.
Khalid KhanDepartment of Animal Breeding and Genetics, University of Veterinary and Animal Sciences, Swat, Pakistan.
Amel Ayari-AkkariBiology Department, College of Science, King Khalid University, P.O. Box 960, Abha, Saudi Arabia.

Funding

Higher Education Commision, Pakistan HEC-NRPU Project No.16746
6 · The paper itself

Abstract

In the present study, the effects of age and sex on the expression of meat quality marker genes such as the FASN (Fatty Acid Synthase), C/EBPα (CCAAT Enhancer Binding Protein Alpha), PLIN1 (Perilipin-1), PPARγ (Peroxisome Proliferator Activated Receptor Gamma), and SIRT1 (Sirtuin1) were explored. The total RNA was extracted, the cDNA library was constructed, and mRNA was quantified through qRT-PCR from the samples of young and mature sheep of male and female Balkhi breeds. Moreover, the correlation of expression levels of these genes with body and measurement traits was also explored in Balkhi sheep. Age and sex significantly (P < 0.05) affected the expression of the FASN, C/EBPα, PLIN1, and SIRT1 genes. The expression of FASN and PLIN1 genes was higher (P < 0.05) in female Balkhi sheep, whereas the expression levels of SIRT1 and C/EBPα were higher (P < 0.05) in young male Balkhi sheep. The correlation study revealed the significant (P < 0.05) and positive effect of FASN, C/EBPα, and PPARγ on body measurements such as heart girth, body length, and body weight in young Balkhi sheep. At the same time, the SIRT1 gene correlated significantly (P < 0.05) and negatively with body length and height at the chest in mature male Balkhi sheep. This study revealed the importance and potential for genetic selection and breeding strategies by targeting these gene markers to improve meat production and quality in different age and sexes of the Balkhi sheep.

Indexed as

MeatSheep, DomesticAge FactorsAnimalsCCAAT-Enhancer-Binding Protein-alphaFatty Acid Synthase, Type IFemaleGenetic MarkersMalePerilipin-1PPAR gammaSex FactorsSirtuin 1CCAAT-Enhancer-Binding Protein-alphaFatty Acid Synthase, Type IGenetic MarkersPerilipin-1PPAR gammaSirtuin 1Balkhi sheepBody measurementsCorrelationExpressionMeat quality markers

Identifiers

PMID40691340

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