Evidence map›Paper›PMID 40691285›Full record

ArticleScientific reports2025

Whole blood vs saline for MAP restoration in anesthetized piglets after non-traumatic hemorrhagic shock: an experimental study.

Fabien Coisy, Dino Tikvesa, Florian Ajavon, Augustin Gamel, Laura Grau-Mercier, Thomas Sanchez, Marylène Bacle, Jean-Yves Lefrant, Thibaut Markarian, Xavier Bobbia

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabien CoisyIMAGINE UR UM 103, Montpellier University, Department of Emergency Medicine, Nîmes University Hospital, 4 Place du Pr Robert Debré, 30900, Nîmes, France. fabien.coisy@gmail.com.
Dino TikvesaIMAGINE UR UM 103, Montpellier University, Department of Emergency Medicine, Montpellier University Hospital, Montpellier, France.
Florian AjavonDepartment of Emergency Medicine, Nimes University Hospital, Nîmes, France.
Augustin GamelDepartment of Emergency Medicine, Nimes University Hospital, Nîmes, France.
Laura Grau-MercierDepartment of Emergency Medicine, Nimes University Hospital, Nîmes, France.
Thomas SanchezIMAGINE UR UM 103, Montpellier University, Department of Emergency Medicine, Montpellier University Hospital, Montpellier, France.
Marylène BacleRAM-PTNIM, Medical School of Nimes, Montpellier University, Montpellier, France.
Jean-Yves LefrantIMAGINE UR UM 103, Montpellier University, Department of Critical Care, Nîmes University Hospital, Nîmes, France.
Thibaut MarkarianDepartment of Emergency Medicine, Timone University Hospital, Marseille, France.
Xavier BobbiaIMAGINE UR UM 103, Montpellier University, Department of Emergency Medicine, Montpellier University Hospital, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the management of hemorrhagic shock (HS), the restoration of adequate mean arterial pressure (MAP) while minimizing complications is critical. Whole blood (WB) has demonstrated physiological advantages over crystalloids such as normal saline (NS), yet direct comparisons in non-traumatic HS remain scarce. This study sought to evaluate the volume and hemodynamic efficacy of WB compared to NS in achieving a MAP of 60 mmHg in a porcine model of non-traumatic HS. The WB requirement and the NS volume necessary to restore MAP were 12 [10-14] and 23 [20-24] mL·kg

Indexed as

Arterial PressureSaline SolutionShock, HemorrhagicAnimalsDisease Models, AnimalHemodynamicsResuscitationSwineSaline SolutionDamage control resuscitationExperimentalHemorrhagic shockWhole blood

Identifiers

PMID40691285
PMCPMC12280024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.