ArticleBritish journal of cancer2025
Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.
Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Mutational Epidemiology of Childhood Cancer.Clinical chemistry · 2025Review
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6 authors.
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Abstract
backgroundMaternal health during pregnancy appears to impact childhood cancer risk, yet comprehensive studies remain scarce. This study investigates associations between childhood cancer and multiple maternal comorbidities.
methodsA population-based case-control study was conducted using Danish national registers, with maternal health conditions identified from the National Patient Register and Medical Births Registry. We employed the Obstetric Comorbidity Index using ICD-8 and ICD-10 codes. The study population (1977-2013) included 6419 cases and 160484 matched controls. Conditional logistic regression estimated pediatric cancer risk.
resultsA maternal comorbidity score of one or more was linked to acute lymphocytic leukemia (ALL; OR = 1.07, 95%CI: 1.03-1.12), retinoblastoma (OR = 1.08, 95%CI: 0.94-1.23), and rhabdomyosarcoma (OR = 1.11, 95%CI: 0.98-1.26). Pre-existing diabetes (OR = 1.82, 95%CI: 1.28-2.59), previous cesarean delivery (OR = 1.20, 95%CI: 1.02-1.41), and gestational hypertension (OR = 1.27, 95%CI: 1.01-1.59) were associated with increased cancer risks in offspring. Slightly higher risks were noted for non-Hodgkin lymphoma (OR = 1.05, 95%CI: 0.96-1.16) and Burkitt lymphoma (OR = 1.08, 95%CI: 0.92-1.27) among children whose mothers had one or more comorbidities.
conclusionAn obstetric comorbidity index can predict childhood cancer risk. This highlights the need for targeted interventions to reduce adverse health consequences for offspring.
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