Evidence map›Paper›PMID 40691260›Full record

ArticleScientific reports2025

Effects of different sodium concentrations in fluids on brain, lung, and kidney in experimental ischemic stroke.

Camila M Bessa, Adriana L Vilardo, Diogo B Peruchetti, Pedro H L Conceição, Celso Caruso-Neves, Vera L Capelozzi, Denise Battaglini, Chiara Robba, Paolo Pelosi, Manu L N G Malbrain and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Camila M BessaLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil.
Adriana L VilardoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil.
Diogo B PeruchettiDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Pedro H L ConceiçãoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil.
Celso Caruso-NevesLaboratory of Biochemistry and Cell Signaling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Vera L CapelozziDepartment of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Denise BattagliniDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Chiara RobbaDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Manu L N G MalbrainFirst Department of Anesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
Patricia R M RoccoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil.
Pedro L SilvaLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil.
Cynthia S SamaryLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-061, Ilha do Fundão, Rio de Janeiro, 21941-902, RJ, Brazil. cynthiasamary@biof.ufrj.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluid administration is a key component in the management of acute ischemic stroke (AIS). However, the effects of different sodium concentrations in resuscitation fluids, particularly on distal organ function, remain controversial. This study compared the impact of four commonly used fluids-0.9% isotonic saline (ISO), 0.45% hypotonic saline (HYPO), 1.5% hypertonic saline (HYPER), and 5% glucose (GLUCO)-on perilesional brain tissue, lungs, and kidneys following AIS. AIS was induced in 28 male Wistar rats. Three hours after stroke induction, animals were randomized to receive one of the four fluids. In the brain, the ISO group showed significantly higher expression of versican and hyaluronan compared to the HYPER group (p = 0.022 and p = 0.018, respectively). Conversely, the HYPER group exhibited significantly elevated levels of interleukin-1β (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), and zonula occludens-1 (ZO-1) compared to the GLUCO group (p = 0.01, p = 0.02, and p = 0.006, respectively). In the lungs, the ISO group demonstrated less alveolar collapse and pulmonary edema compared to the HYPER and HYPO groups (p = 0.01 and p = 0.007, respectively). In the kidneys, both the ISO and HYPO groups showed significantly less brush-border injury than the HYPER group (p = 0.007 and p = 0.032, respectively). Furthermore, blood chloride levels declined over time in the ISO group compared to the others. In conclusion, isotonic fluid administration resulted in the least amount of injury to the brain, lungs, and kidneys in this experimental model of AIS, supporting its use as a preferred resuscitation strategy in the acute phase.

Indexed as

BrainFluid TherapyIschemic StrokeKidneyLungSodiumAnimalsDisease Models, AnimalMaleRatsRats, WistarSaline SolutionSaline Solution, HypertonicSaline SolutionSaline Solution, HypertonicSodiumAcute ischemic strokeBrain damageFluidsInflammationSodium concentration

Identifiers

PMID40691260
PMCPMC12280188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.