Evidence map›Paper›PMID 40691257›Full record

ArticleScientific reports2025

Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice.

Perry C Caviness, Oxana P Lazarenko, Michael L Blackburn, Jin-Ran Chen

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Perry C CavinessArkansas Children's Nutrition Center, Little Rock, AR, 72205, USA.
Oxana P LazarenkoArkansas Children's Nutrition Center, Little Rock, AR, 72205, USA.
Michael L BlackburnArkansas Children's Nutrition Center, Little Rock, AR, 72205, USA.
Jin-Ran ChenArkansas Children's Nutrition Center, Little Rock, AR, 72205, USA. chenjinran@uams.edu.

Funding

The role of oxidative stress in alcohol-induced osteopeniaR37AA018282 · NIAAA · LSU HEALTH SCIENCES CENTER · PI RONIS, MARTIN J J · 2016 to 2025
$4.7M
NIAAA NIH HHS R37 AA018282NIH R01 project sub-awarded to JRC R37 AA18282USDA-ARS Project 6026-10700-001-000D
6 · The paper itself

Abstract

Blueberry metabolite-derived phenolic acids are thought to suppress bone resorption via interactions with the G protein-coupled receptor 109A (GPR109A). Previously, global GPR109A knockout (GPR109A

Indexed as

Bone DevelopmentGene DeletionMyeloid CellsReceptors, G-Protein-CoupledAnimalsCancellous BoneFemaleMaleMiceMice, KnockoutSex CharacteristicsSex FactorsTibiaX-Ray MicrotomographyHcar1 protein, mouseHcar2 protein, mouseReceptors, G-Protein-CoupledBoneOsteoclastSexual dimorphismµCT

Identifiers

PMID40691257
PMCPMC12280110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.