ArticleScientific reports2025
Wound healing properties and antibiofilm activity of hydrogel matrix containing nitric oxide, silver nanoparticles, and ciprofloxacin against Pseudomonas aeruginosa burn wound infection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing.Drug delivery · 2026Article
- Highly Efficient Photodynamic Inactivation of Multidrug-resistant Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter baumannii Strains by Toluidine Blue-graphene Oxide Quantum Dot/Ag Nanoparticle Conjugate.Current microbiology · 2026Article
- In Vivo Wound Healing Activity Using Pomegranate Peel Derived - Silver Nanoparticle Hydrogel Pre-Exposed with 660 nm Red Light.Biological trace element research · 2026Article
- Hydrogel-Based Platforms for Wound Care: Integrated Strategies for Antimicrobial Delivery and Biofilm Management.Gels (Basel, Switzerland) · 2026Review
- Bacterial Cellulose Hydrogel Incorporating Silver Nanoparticles: A Nanobiotechnological Approach for Skin Infections Caused by MRSA and MRSE.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Exploration of recent advancements of nanoparticle-based therapeutics emphasis on diabetic-related chronic wound management: a comprehensive review.Archives of pharmacal research · 2026Review
- Polyphenolic compounds inFrontiers in pharmacology · 2026Review
- Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026Review
- Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing.Asian journal of pharmaceutical sciences · 2025Review
- Article
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Abstract
The high antibiotic resistance of Pseudomonas aeruginosa has led to significant issues and delays in wound healing, resulting in disruptions to the healing process. The present study evaluated the antibacterial effects and wound healing properties of a hydrogel matrix containing nitric oxide, silver nanoparticles, and ciprofloxacin (Hy-NO-Ag-Cip) against multi-drug-resistant (MDR) P. aeruginosa. The MDR P. aeruginosa was isolated from patients with burn wound infection. Hy-NO-Ag-Cip was synthesized, and its physicochemical characteristics were evaluated. The in vitro antibacterial and anti-biofilm effects of Hy-NO-Ag-Cip were analyzed. Burn wound infections were induced in 25 rats, and topical application was conducted to assess the antibacterial efficacy and wound healing characteristics of Hy-NO-Ag-Cip. The results showed that the fabricated hydrogels have a porous structure, with interconnected pores. The spectra of the formulated hydrogel loaded with AgNPs and the drug showed bands with similar frequencies and shapes to those of the final hydrogel. The Hy-NO-Ag-Cip minimum inhibitory concentration (MIC) was 250 µg/mL, and the 2× MIC of this hydrogel reduced mature biofilm by 65%. There was no toxic effect observed at the MIC concentration of Hy-NO-Ag-Cip on the L929 cell line. In the wound healing process, the group treated with Hy-NO-Ag-Cip exhibited a greater epithelial thickness, indicating enhanced wound healing compared to the other group. Hy-NO-Ag-Cip enhances antibiotic accumulation at the infection site through a controlled drug release, resulting in a substantial antibacterial action and improved wound healing.
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