Evidence map›Paper›PMID 40691255›Full record

ArticleScientific reports2025

Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells.

Joyce Appiah-Kubi, Yuan Yuzhe, Takeo Kuwata, Hiromi Terasawa, Perpetual Nyame, Wright Ofotsu Amesimeku, Md Jakir Hossain, Shuzo Matsushita, Tomohiro Sawa, Yosuke Maeda and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joyce Appiah-KubiDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Yuan YuzheGraduate School of Science, Technology and Innovation, Kobe University, Hyogo, 650-0047, Japan.
Takeo KuwataCollaborative Research Program with the Chemo-Sero-Therapeutic Research Institute for Anti-viral Agents and Hematological Diseases, Joint Research Center for Human Retrovirus Infection, Kumamoto, 860-0811, Japan.
Hiromi TerasawaDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Perpetual NyameDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Wright Ofotsu AmesimekuDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Md Jakir HossainDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Shuzo MatsushitaCollaborative Research Program with the Chemo-Sero-Therapeutic Research Institute for Anti-viral Agents and Hematological Diseases, Joint Research Center for Human Retrovirus Infection, Kumamoto, 860-0811, Japan.
Tomohiro SawaDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Yosuke MaedaDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Shinji HaradaDepartment of Medical Virology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Keisuke YusaGraduate School of Science, Technology and Innovation, Kobe University, Hyogo, 650-0047, Japan.
Kazuaki MondeDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan. monde@kumamoto-u.ac.jp.

Funding

Japan Agency for Medical Research and Development 21fk0410026h0001Japan Society for the Promotion of Science 26501008
6 · The paper itself

Abstract

For the entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells, CCR5 functions as a coreceptor following the binding of the envelope glycoprotein gp120 to the receptor CD4. While CD4 is known to be strongly downregulated after infection, the fate of CCR5 post-infection remains unclear. We investigated the surface expression of CCR5 on PM1/CCR5 cells following infection with HIV-1

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV Envelope Protein gp120HIV InfectionsReceptors, CCR5Cell LineHumansVirionVirus InternalizationCCR5 protein, humangp120 protein, Human immunodeficiency virus 1HIV Envelope Protein gp120Receptors, CCR5AssemblyCCR5 epitope maskCCR5 incorporationHIV-1

Identifiers

PMID40691255
PMCPMC12279923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.