ArticleNature chemistry2025
Strong dipole-promoted N-O bond hydrogenolysis enables ampere-level electrosynthesis of methylamine.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Heterogeneous Indirect Redox Electrocatalysis in Electrolyte.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Electrocatalytic C─N Coupling in Aqueous Solutions for High-Value Product Synthesis.Angewandte Chemie (International ed. in English) · 2026Review
- Enantioselective Copper-Catalyzed Synthesis of Hydroxylamines via Hydrofunctionalization of Alkenes using Nitroalkanes.Journal of the American Chemical Society · 2026Article
- Engineering d-orbital of copper single-atom sites toward industrial-level electrocatalytic methanation.Nature communications · 2026Article
- Expedient access to methylamine with potential.Nature chemistry · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The electrochemical hydrogenolysis of nitromethane in water could provide a sustainable route for accessing methylamine, one of the simplest alkyl amines and most commonly used bulk chemicals. However, present efforts achieve only methylamine selectivities below 10% due to the ineffective N-O bond activation of the N-methylhydroxylamine intermediate. Here we design a copper electrocatalyst with abundant low-coordination sites to enable the conversion of nitromethane to methylamine with 99% selectivity and 97% Faradaic efficiency at a low potential. The low-coordination copper sites induce a large dipole moment upon N-methylhydroxylamine adsorption to promote N‒O hydrogenolysis. Altering the pH changes the rate-determining step, resulting in a pH-dependent volcano trend for methylamine production. We demonstrate ampere-level production of 1.5 mol of methylamine alongside easy product purification, gram-scale synthesis of deuterated methylamine and drugs, and hydrogenolysis of other N‒O bonds. This work offers a promising, general approach to alkyl N-O bond hydrogenolysis that could compete with traditional thermochemical routines.
Identifiers
40691248What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.