ArticleScientific reports2025
Positive selection of efficient ethanol producers from xylose at 45 °C in the yeast Ogataea polymorpha.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Lignocellulosic biomass fermentation: a roadmap for Candida famata and Ogataea polymorpha.FEMS yeast research · 2025Review
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4 authors.
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Abstract
This research presents a method for the positive selection of mutants with improved xylose and L-arabinose fermentation in the thermotolerant, naturally xylose-utilizing yeast Ogataea polymorpha which is based on isolation of the mutants growing on L-arabinose as sole carbon and energy source. Whole-genome sequencing of the most efficient xylose-fermenting strain, A107, revealed mutations in the API1 and IRA1 genes, which are homologous to bacterial arabinose-5-phosphate isomerase and the Ras-GTPase activating domain in Saccharomyces cerevisiae, respectively. Disruption of the IRA1 gene increased ethanol production during the fermentation of xylose and L-arabinose in O. polymorpha at 45 °C. Overexpression of the API1 gene specifically enhanced L-arabinose fermentation without affecting xylose fermentation. The most productive mutant strain accumulated 20.91 g/L of ethanol in a xylose-containing medium at 45 °C, exceeding the ethanol accumulation level of the wild-type strain (0.40 g/L) by over 50 times. This strain holds potential for application in simultaneous saccharification and fermentation (SSF) processes.
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